Prevention of Capsular Contracture Using Leukotriene Antagonists.
Abstract
[BACKGROUND] Capsular contracture is a common occurrence in plastic surgery, with a prevalence varying from 0.5 percent up to 30 percent. Although the standard treatment is capsulectomy, alternative treatments have been studied, such as the use of leukotriene inhibitors. These drugs have recently been evaluated in the prophylaxis of contracture. The authors aimed to assess the efficacy of montelukast (Singulair) in the prevention of capsular contracture in patients undergoing mammaplasty with textured silicone prostheses.
[METHODS] The authors followed 82 patients (164 breasts) for a minimum of 2 years. Of these, 37 were administered montelukast.
[RESULTS] The number of affected patients and the severity were higher among the 45 patients who did not use montelukast.
[CONCLUSION] The prophylactic use of Singulair was, in this sample, shown to be effective in helping to reduce the incidence of capsular contracture.
[CLINICAL QUESTION/LEVEL OF EVIDENCE] Therapeutic, III.
[METHODS] The authors followed 82 patients (164 breasts) for a minimum of 2 years. Of these, 37 were administered montelukast.
[RESULTS] The number of affected patients and the severity were higher among the 45 patients who did not use montelukast.
[CONCLUSION] The prophylactic use of Singulair was, in this sample, shown to be effective in helping to reduce the incidence of capsular contracture.
[CLINICAL QUESTION/LEVEL OF EVIDENCE] Therapeutic, III.
추출된 의학 개체 (NER)
| 유형 | 영어 표현 | 한국어 / 풀이 | UMLS CUI | 출처 | 등장 |
|---|---|---|---|---|---|
| 합병증 | capsular contracture
|
피막구축 | dict | 4 | |
| 시술 | mammaplasty
|
유방성형술 | dict | 1 | |
| 해부 | capsular
|
scispacy | 1 | ||
| 약물 | Leukotriene
|
C0023545
Leukotrienes
|
scispacy | 1 | |
| 약물 | montelukast
|
C0298130
montelukast
|
scispacy | 1 | |
| 약물 | Singulair
|
C0595724
Singulair
|
scispacy | 1 | |
| 약물 | silicone
|
C0037114
silicones
|
scispacy | 1 | |
| 약물 | Leukotriene Antagonists
|
scispacy | 1 | ||
| 약물 | [BACKGROUND] Capsular
|
scispacy | 1 | ||
| 질환 | contracture
|
C0009917
Contracture
|
scispacy | 1 | |
| 기타 | patients
|
scispacy | 1 |
MeSH Terms
Acetates; Adolescent; Adult; Brazil; Breast Implants; Cohort Studies; Cyclopropanes; Female; Follow-Up Studies; Humans; Implant Capsular Contracture; Leukotriene Antagonists; Logistic Models; Mammaplasty; Middle Aged; Multivariate Analysis; Primary Prevention; Quinolines; Retrospective Studies; Risk Assessment; Sulfides; Treatment Outcome; Young Adult
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