Treatment and outcome of breast implant-associated anaplastic large cell lymphoma: a population-based cohort study in the Netherlands.
Abstract
The optimal treatment of patients with breast implant-associated anaplastic large cell lymphoma (BIA-ALCL) that underwent incomplete resection, have advanced stage disease or relapse after resection remains unknown. We describe the treatment and outcome of all 91 Dutch BIA-ALCL patients up to 2023. Primary outcomes were progression-free survival (PFS) and overall survival (OS). Ann Arbor stage I was frequently encountered (74%) compared to stage II (13%) and stage IV (11%). First-line treatment of stage I patients consisted mostly of surgery (88%). Stage II patients were treated with chemotherapy (CT) (67%) or underwent surgery (33%). All stage IV patients received CT. In total, 30% of patients ( = 27) received CT. Relapse frequently occurred (60%) in stage IV disease. The 2-year PFS and OS for stage I, II and IV were 89 and 98%, 83 and 92% and 50 and 90%, respectively. Following second-line treatment, all but one patient remained in remission.
추출된 의학 개체 (NER)
| 유형 | 영어 표현 | 한국어 / 풀이 | UMLS CUI | 출처 | 등장 |
|---|---|---|---|---|---|
| 해부 | breast
|
유방 | dict | 2 | |
| 합병증 | anaplastic large cell lymphoma
|
보형물연관 역형성대세포림프종 | dict | 2 | |
| 합병증 | bia-alcl
|
보형물연관 역형성대세포림프종 | dict | 2 | |
| 약물 | second-line
|
scispacy | 1 | ||
| 질환 | breast implant-associated anaplastic large cell lymphoma
|
C4528210
Breast implant-associated anaplastic large-cell lymphoma
|
scispacy | 1 | |
| 질환 | stage disease
|
C0699749
disease stage
|
scispacy | 1 | |
| 질환 | Ann Arbor stage I
|
C4683555
Ann Arbor Stage
|
scispacy | 1 | |
| 질환 | BIA-ALCL patients
|
scispacy | 1 | ||
| 기타 | patients
|
scispacy | 1 | ||
| 기타 | patient
|
scispacy | 1 |
MeSH Terms
Humans; Lymphoma, Large-Cell, Anaplastic; Female; Middle Aged; Netherlands; Breast Implants; Aged; Adult; Neoplasm Staging; Breast Neoplasms; Antineoplastic Combined Chemotherapy Protocols; Treatment Outcome; Aged, 80 and over; Combined Modality Therapy; Prognosis; Retrospective Studies
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