Diagnosis of breast implant associated anaplastic large cell lymphoma by analysis of cytokines in peri-implant seromas.
Abstract
More than 1300 women with breast implants have developed an anaplastic large cell lymphoma (ALCL) in fluid (seroma) around their implant. More often, seromas are due to benign causes, for example, capsule contracture, leakage, or trauma. Our report in American Journal of Hematology identified several cytokines (IL-9, IL-10, IL-13) as significantly elevated only in seromas due to ALCL. We further showed that the most robust biomarker, IL-10, could be detected by a lateral flow assay (similar to COVID detection) within minutes allowing physicians to quickly plan management, eliminate or reduce costly testing and patient time away from family. Early detection of ALCL in seromas before infiltration may avoid need for cytotoxic or immunotherapy and is possibly life-saving.
추출된 의학 개체 (NER)
| 유형 | 영어 표현 | 한국어 / 풀이 | UMLS CUI | 출처 | 등장 |
|---|---|---|---|---|---|
| 해부 | breast
|
유방 | dict | 2 | |
| 합병증 | anaplastic large cell lymphoma
|
보형물연관 역형성대세포림프종 | dict | 2 | |
| 해부 | lateral
|
scispacy | 1 | ||
| 합병증 | peri-implant seromas
|
scispacy | 1 | ||
| 합병증 | seromas
|
scispacy | 1 | ||
| 합병증 | seroma
|
장액종 | dict | 1 | |
| 합병증 | breast implant associated
|
보형물연관 역형성대세포림프종 | dict | 1 | |
| 약물 | COVID
|
scispacy | 1 | ||
| 질환 | breast implant
|
C0178391
breast implant procedure
|
scispacy | 1 | |
| 질환 | anaplastic
|
C0205618
Undifferentiated
|
scispacy | 1 | |
| 질환 | peri-implant seromas
|
scispacy | 1 | ||
| 질환 | ALCL
→ anaplastic large cell lymphoma
|
C0206180
Ki-1+ Anaplastic Large Cell Lymphoma
|
scispacy | 1 | |
| 질환 | seromas
|
C0262627
Seroma
|
scispacy | 1 | |
| 질환 | contracture
|
C0009917
Contracture
|
scispacy | 1 | |
| 질환 | trauma
|
C0043251
Wounds and Injuries
|
scispacy | 1 | |
| 질환 | benign
|
scispacy | 1 | ||
| 질환 | capsule
|
scispacy | 1 | ||
| 기타 | women
|
scispacy | 1 | ||
| 기타 | IL-9
|
scispacy | 1 | ||
| 기타 | IL-10
|
scispacy | 1 | ||
| 기타 | IL-13
|
scispacy | 1 | ||
| 기타 | patient
|
scispacy | 1 |
MeSH Terms
Female; Humans; Lymphoma, Large-Cell, Anaplastic; Breast Implants; Interleukin-10; Seroma; Cytokines; COVID-19; Breast Neoplasms; COVID-19 Testing
🔗 함께 등장하는 도메인
이 논문이 속한 카테고리와 같은 논문에서 자주 함께 다뤄지는 카테고리들
관련 논문
- The impact of three-dimensional simulation and virtual reality technologies on surgical decision-making and postoperative satisfaction in aesthetic surgery: a preliminary study.
- Cutaneous fistula of the breast: A complication of cosmetic autologous fat transfer.
- Epidermal inclusion cyst after breast reduction mammoplasty.
- The Plastic Surgery In-Service Examination: A Scoping Review.
- Clinical outcomes of synthetic absorbable mesh use in breast surgery: First case series in reconstruction and aesthetic mastopexy.