Establishment and characterization of a novel breast implant-associated anaplastic large cell lymphoma cell line and PDX model (BIA-XR1) with a unique KRAS mutation.
Abstract
Breast implant-associated anaplastic large cell lymphoma (BIA-ALCL) is an uncommon T-cell lymphoma type with distinct clinical, molecular and genetic features. Establishment of BIA-ALCL cell lines and patient-derived xenograft (PDX) models are essential experimental tools to investigate the molecular pathogenesis of the disease. We characterized a novel BIA-ALCL cell line and PDX model, named BIA-XR1, derived from a patient with textured breast implant who developed lymphoma. Next-generation sequencing revealed a STAT3 mutation, commonly detected in BIA-ALCL, and a unique KRAS mutation reported for the first time in this lymphoma type. Both JAK/STAT3 and RAS/MEK/ERK oncogenic pathways were activated in BIA-XR1, which are targetable with clinically available agents.
추출된 의학 개체 (NER)
| 유형 | 영어 표현 | 한국어 / 풀이 | UMLS CUI | 출처 | 등장 |
|---|---|---|---|---|---|
| 합병증 | bia-alcl
|
보형물연관 역형성대세포림프종 | dict | 4 | |
| 해부 | breast
|
유방 | dict | 3 | |
| 합병증 | anaplastic large cell lymphoma
|
보형물연관 역형성대세포림프종 | dict | 2 | |
| 해부 | BIA-ALCL cell lines
|
scispacy | 1 | ||
| 해부 | BIA-ALCL cell line
|
scispacy | 1 | ||
| 약물 | PDX
→ patient-derived xenograft
|
scispacy | 1 | ||
| 질환 | breast implant-associated anaplastic large cell lymphoma cell line and PDX
|
C4528210
Breast implant-associated anaplastic large-cell lymphoma
|
scispacy | 1 | |
| 질환 | Breast implant-associated anaplastic large cell lymphoma
|
C4528210
Breast implant-associated anaplastic large-cell lymphoma
|
scispacy | 1 | |
| 질환 | T-cell lymphoma
|
C0079772
T-Cell Lymphoma
|
scispacy | 1 | |
| 질환 | breast implant-associated anaplastic large cell lymphoma cell line
|
scispacy | 1 | ||
| 질환 | xenograft
|
scispacy | 1 | ||
| 질환 | lymphoma
|
scispacy | 1 | ||
| 기타 | patient
|
scispacy | 1 | ||
| 기타 | STAT3
|
scispacy | 1 | ||
| 기타 | JAK/STAT3
|
scispacy | 1 |
MeSH Terms
Lymphoma, Large-Cell, Anaplastic; Humans; Female; Breast Implants; Proto-Oncogene Proteins p21(ras); Cell Line, Tumor; Animals; Mutation; Mice; Breast Neoplasms; Xenograft Model Antitumor Assays; STAT3 Transcription Factor; Disease Models, Animal; Middle Aged
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