Molecular Drivers of Breast Implant-Associated Anaplastic Large Cell Lymphoma.
Abstract
Breast implant-associated anaplastic large cell lymphoma (BIA-ALCL) is a rare T-cell lymphoproliferative disorder occurring in patients with breast implants. Genomic characterization performed in BIA-ALCL to date has demonstrated qualitatively similar molecular abnormalities to those seen in its more common counterpart [ALK-negative systemic anaplastic large cell lymphoma (sALCL)] including JAK/STAT activation and MYC/TP53 dysregulation. Despite these observed similarities at the molecular level, the outcomes of sALCL and BIA-ALCL are markedly different with sALCL typically associated with an aggressive course and inferior outcomes compared with BIA-ALCL. This review describes the findings of high-throughput sequencing and other genomic characterization to date in BIA-ALCL and the insights these studies have given into the molecular drivers of this rare lymphoma subtype.
추출된 의학 개체 (NER)
| 유형 | 영어 표현 | 한국어 / 풀이 | UMLS CUI | 출처 | 등장 |
|---|---|---|---|---|---|
| 합병증 | bia-alcl
|
보형물연관 역형성대세포림프종 | dict | 5 | |
| 해부 | breast
|
유방 | dict | 3 | |
| 합병증 | anaplastic large cell lymphoma
|
보형물연관 역형성대세포림프종 | dict | 3 | |
| 해부 | T-cell
|
scispacy | 1 | ||
| 질환 | Breast Implant-Associated Anaplastic
|
scispacy | 1 | ||
| 질환 | Breast implant-associated anaplastic large cell lymphoma
|
C4528210
Breast implant-associated anaplastic large-cell lymphoma
|
scispacy | 1 | |
| 질환 | T-cell lymphoproliferative disorder
|
C5555431
T/NK-Cell Lymphoproliferative Disorder
|
scispacy | 1 | |
| 질환 | ALK-negative
|
scispacy | 1 | ||
| 질환 | anaplastic
|
C0205618
Undifferentiated
|
scispacy | 1 | |
| 질환 | sALCL
→ systemic anaplastic large cell lymphoma
|
C0206180
Ki-1+ Anaplastic Large Cell Lymphoma
|
scispacy | 1 | |
| 질환 | lymphoma
|
scispacy | 1 | ||
| 기타 | JAK/STAT
|
scispacy | 1 |
MeSH Terms
Adult; Aged; Anaplastic Lymphoma Kinase; Breast Implantation; Breast Implants; Breast Neoplasms; Female; Genetic Predisposition to Disease; Genomics; Humans; Lymphoma, Large-Cell, Anaplastic; Middle Aged; Prognosis
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