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Fat harvesting protocol for enhanced stem cell viability - pilot study.
[OBJECTIVE] Adipose tissue is used in several specialties to obtain Adipose-derived Stem Cells (ASC) and fat derivatives. Several studies analyze protocols for harvesting fat tissues. However, these studies showed inconclusive data regardin…
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Prognostic Nuances in the Microsurgical Resection of Arteriovenous Malformations in Areas of Critical Brain Function: A 25-Year Retrospective Cohort Study.
[BACKGROUND AND OBJECTIVES] Microsurgical grading scales are widely used prognostic tools in the preoperative assessment of arteriovenous malformations (AVMs); however, a key shortcoming of commonly used systems is the consideration of "elo…
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Single-Institution Analysis of Immediate and Delayed Jaw Reconstruction.
[BACKGROUND] Traditional methods of mandibular reconstruction commonly utilize the fibula-free flap (FFF) with delayed placement of dental prostheses. Recently, immediate prosthesis placement has been introduced to eliminate the period of e…
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Urethral reconstruction using a preputial mucosa free flap and autologous Mesenchymal Stromal Cells in a male alpaca (Vicugna pacos).
Like small ruminants, alpacas are prone to urethral obstruction, commonly caused by urolithiasis. Surgical intervention, such as perineal urethrostomy, is often necessary, though recurrent strictures and impaired healing pose significant ch…
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A Fibrous-Porous Microsphere-Based Composite Filler for Synchronized Immediate and Long-Term Soft Tissue Restoration.
Current injectable fillers often suffer from a transient efficacy and insufficient early stage improvement. To address this, we developed a composite dermal filler consisting of hyaluronic acid (HA) and poly-L-lactic acid-methoxypolyethylen…
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A case report exploring the use of subcutaneous Botox for the treatment of neuropathic pain in active head and neck cancer.
Patients with head and neck cancer commonly experience severe neuropathic pain. This pain is often challenging to treat and may be refractory to standard analgesic approaches. We describe the use of subcutaneous Botox injections to manage p…
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Variant-aware computational assessment of neutralizing antibody binding robustness to botulinum toxin A.
Botulinum neurotoxin type A (BoNT/A) is a widely used biologic therapeutic, yet the influence of natural toxin sequence variation on the stability of neutralizing antibody binding remains poorly understood. In this study, we performed a com…
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GLP-1 Receptor Agonist Use and Wound Outcomes After Free Flap Breast Reconstruction.
Background Glucagon-like peptide-1 receptor agonists (GLP-1s) are increasingly used for glycemic control and weight loss, but their impact on surgical wound complications remains unclear. Some studies suggest GLP-1s reduce complications suc…
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Outcomes of folded submental flap reconstruction for full-thickness cheek defects in advanced oral cavity cancer.
[OBJECTIVE] Full-thickness cheek defects resulting from advanced oral cavity cancer pose significant reconstructive challenges, with both functional and aesthetic implications. Although free flap remains the gold standard, it is resource-in…
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Reconsideration of microsurgery for endovascularly high-risk ruptured vertebral artery dissection.
[BACKGROUND] Endovascular therapy is commonly used for ruptured vertebral artery dissecting aneurysm (VADA); however, complications such as medullary infarction and posterior inferior cerebellar artery (PICA)-related ischemia remain concern…
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Stereotactic Radiosurgery for Brain Arteriovenous Malformations: A Radiosurgery Society Case-Based Guideline.
[PURPOSE] Brain arteriovenous malformations (AVMs) are high-risk vascular anomalies associated with hemorrhage, neurological morbidity, and mortality. Stereotactic radiosurgery (SRS) is a well-established, non-invasive treatment that achiev…
- CMS Botox Coverage Updates: Key Requirements for Urologic Use.
- Comment on: "Efficacy of botulinum toxin injection in treating primary inferior oblique overaction: A retrospective cohort study".
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Beyond spasticity reduction: botulinum toxin-a injection is associated with changes in abnormal flexor synergies of the upper limb in chronic stroke.
[OBJECTIVE] This study aimed to investigate the association between botulinum toxin type A treatment and changes in spasticity and abnormal flexor synergies in patients with chronic stroke. [SUBJECTS] Twenty-eight patients with chronic str…
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Effect of Botulinum Toxin Injection Intervals on the Irreversibility of Targeted Muscle Paralysis: An Electromyographic Study.
[BACKGROUND] Botulinum neurotoxin A (BoNT-A) is widely used clinically, yet its temporary effects require repeated injections that increase cost and inconvenience. Claims that repeated BoNT-A use alters efficacy lack rigorous evaluation. Un…
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Correction of tear trough deformity in young patients without eyebags using orbital fat reposition and release of tear trough ligament.
[BACKGROUND] Tear trough deformity (TTD) is a periorbital hollow extending from the medial canthus to the midpupillary line, which is mainly caused by the traction of the tear trough ligament (TTL). This study aimed to present a retroseptal…
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Augmentation Rhinoplasty in Asian Patients.
[AIM AND BACKGROUND] Asian rhinoplasty presents unique challenges due to distinct anatomical features, including a low nasal dorsum, weak cartilaginous framework, and thick soft tissue envelope. This article examines contemporary surgical a…
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Refining the SPLF Graft: Innovations in Revision Rhinoplasty.
Reconstructing the dorsum in revision rhinoplasty remains a complex challenge. Traditional methods such as solid rib grafts and diced cartilage fascia (DCF) grafts present significant limitations, including warping, displacement, and insuff…
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Piezoelectric Versus Conventional Rhinoplasty: A GRADE-assessed Systematic Review and Meta-analysis of Randomized Controlled Trials.
Piezoelectric osteotomy may reduce postoperative morbidity after rhinoplasty, but time-based effects remain uncertain. We aimed to understand the time-based effectiveness and safety of piezoelectric osteotomy versus conventional method. We …
- One-stage scalp composite tissue transplantation for the correction of pinched nose deformity in Asian patients undergoing revision rhinoplasty.