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9건 · 최신순-
OnabotulinumtoxinA alters pro- and anti-inflammatory dural macrophage response to CSD in female mice.
AimCortical spreading depression (CSD), the neural correlate of migraine aura, has been shown to cause activation of dural nociceptive neurons as well as immune cells, among which macrophages (MPs) are the most abundant and reactive. Onabot…
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Mapping Dural and Periosteal SV2C, a Botulinum Toxin A Receptor, in the Mouse.
[OBJECTIVES] There has been a long-standing debate over the presence or absence of receptors for botulinum toxin A (BoNT/A) in cephalic areas relevant to migraine pathophysiology and onabotulinumtoxinA (onabotA) sites of action in migraine …
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Exploring the effects of extracranial injections of botulinum toxin type A on activation and sensitization of central trigeminovascular neurons by cortical spreading depression in male and female rats.
[BACKGROUND] OnabotulinumtoxinA (onabotA), is assumed to achieve its therapeutic effect in migraine through blocking activation of unmyelinated meningeal nociceptors and their downstream communications with central dura-sensitive trigeminov…
- The opportunity cost of operating: Infertility increases among female plastic surgeons.
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OnabotulinumtoxinA alters inflammatory gene expression and immune cells in chronic headache patients.
Occipital headache, the perception of pain in the back of the head, is commonly described by patients diagnosed with migraine, tension-type headache, and occipital neuralgia. The greater and lesser occipital nerves play central role in the …
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Long-Term Observational Results from the ASPIRE Study: OnabotulinumtoxinA Treatment for Adult Lower Limb Spasticity.
[INTRODUCTION] OnabotulinumtoxinA treatment for spasticity varies according to numerous factors and is individualized to meet treatment goals. [OBJECTIVE] To explore real-world onabotulinumtoxinA utilization and effectiveness in patients w…
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Early onset of effect of onabotulinumtoxinA for chronic migraine treatment: Analysis of PREEMPT data.
[BACKGROUND] The Phase 3 REsearch Evaluating Migraine Prophylaxis Therapy (PREEMPT) trials demonstrated efficacy/tolerability of onabotulinumtoxinA for headache prevention in adults with chronic migraine. This post hoc analysis assessed tim…
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FORWARD Study: Evaluating the Comparative Effectiveness of OnabotulinumtoxinA and Topiramate for Headache Prevention in Adults With Chronic Migraine.
[OBJECTIVE] To compare effectiveness of onabotulinumtoxinA and topiramate for chronic migraine (CM) prevention. [BACKGROUND] The efficacy* of onabotulinumtoxinA and topiramate has been established in placebo-controlled randomized clinical …
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Adult Spasticity International Registry Study: methodology and baseline patient, healthcare provider, and caregiver characteristics.
[OBJECTIVE] The main aim of this study was to determine the utilization patterns and effectiveness of onabotulinumtoxinA (Botox®) for treatment of spasticity in clinical practice. [DESIGN] An international, multicentre, prospective, observ…