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18건 · 최신순-
Biomimetic optimization of silicone breast implant integration: insights into wound healing and the foreign body response.
Breast augmentation is the most prevalent aesthetic surgical procedure worldwide. While silicone breast implants have evolved in terms of safety and biocompatibility, they inevitably trigger a foreign body response (FBR). This complex proce…
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Advances in Silicone Implants Characterization: A Comprehensive Overview of Chemical, Physical and Biological Methods for Biocompatibility Assessment.
Silicone implants are widely used in medical applications, particularly for breast augmentation and reconstruction. However, ongoing concerns regarding their long-term safety and biocompatibility necessitate comprehensive characterization. …
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Advances in surface modifications of the silicone breast implant and impact on its biocompatibility and biointegration.
Silicone breast implants are commonly used for cosmetic and oncologic surgical indications owing to their inertness and being nontoxic. However, complications including capsular contracture and anaplastic large cell lymphoma have been assoc…
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Novel Proteomic Assay of Breast Implants Reveals Proteins With Significant Binding Differences: Implications for Surface Coating and Biocompatibility.
[BACKGROUND] Silicone elastomer, a ubiquitous biomaterial and main constituent of breast implants, has been used for breast augmentation and reconstruction for over 50 years. Breast implants have direct local and purported systemic effects …
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Development, fabrication and evaluation of a novel biomimetic human breast tissue derived breast implant surface.
[UNLABELLED] Breast implant use has tripled in the last decade with over 320,000 breast implant based reconstructions and augmentations performed in the US per annum. Unfortunately a considerable number of women will experience capsular con…
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Functional biocompatibility testing of silicone breast implants and a novel classification system based on surface roughness.
[PURPOSE] Increasing numbers of women undergo breast implantation for cosmetic and reconstructive purposes. Contracture of the fibrous capsule, which encases the implant leads to significant pain and reoperation. Texture, wettability and th…
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Enhanced Contraction of a Normal Breast-Derived Fibroblast-Populated Three-Dimensional Collagen Lattice via Contracted Capsule Fibroblast-Derived Paracrine Factors: Functional Significance in Capsular Contracture Formation.
[BACKGROUND] The authors' aim was to identify morphological, genotypic, and cytokine profiles of normal breast-derived fibroblasts, noncontracted breast implant capsule (Baker grades 1 and 2) fibroblasts, and contracted breast implant capsu…
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Development and functional evaluation of biomimetic silicone surfaces with hierarchical micro/nano-topographical features demonstrates favourable in vitro foreign body response of breast-derived fibroblasts.
Reproducing extracellular matrix topographical cues, such as those present within acellular dermal matrix (ADM), in synthetic implant surfaces, may augment cellular responses, independent of surface chemistry. This could lead to enhanced im…
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Identification of molecular phenotypic descriptors of breast capsular contracture formation using informatics analysis of the whole genome transcriptome.
Breast capsular contracture formation following silicone implant augmentation/reconstruction is a common complication that remains poorly understood. The aim of this study was to identify potential biomarkers implicated in breast capsular c…
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Characterisation of breast implant surfaces and correlation with fibroblast adhesion.
[INTRODUCTION] Capsular contracture formation is a common complication following breast augmentation surgery. Breast implant shells have either a smooth or a textured surface. Smooth surfaces demonstrate a higher incidence of contracture fo…
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Hyaluronan, TSG-6, and inter-α-inhibitor in periprosthetic breast capsules: reduced levels of free hyaluronan and TSG-6 expression in contracted capsules.
[BACKGROUND] The exact mechanism of capsular contracture (CC) is still unknown. The covalent modification of hyaluronan (HA) with the heavy chains (HC) of inter-α-inhibitor (IαI) has been identified as an important pathway in inflammation a…
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Breast implant surface development: perspectives on development and manufacture.
Capsular contracture poses a significant clinical and scientific research challenge for breast surgeons. Some researchers have pointed to the surface features of implant devices as being responsible for the potential tightening and hardenin…
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Tumour necrosis factor-α expression is associated with increased severity of periprosthetic breast capsular contracture.
[BACKGROUND] The pathogenesis of periprosthetic capsular contracture following breast implant surgery is unclear. The aim of this study was to identify the expression of tumour necrosis factor-α (TNF-α), collagen type III α(1) (COL3A1), tra…
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Patterning of novel breast implant surfaces by enhancing silicone biocompatibility, using biomimetic topographies.
[INTRODUCTION AND AIMS] Silicone biocompatibility is dictated by cell-surface interaction and its understanding is important in the field of implantation. The role of surface topography and its associated cellular morphology needs investiga…
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Current implant surface technology: an examination of their nanostructure and their influence on fibroblast alignment and biocompatibility.
[UNLABELLED] Systematic reviews indicate that breast implant texture confers a protective effect on capsular contracture. Fibroblasts are affected by micro- and nanotopographies. Few previous studies have investigated the inherent topograph…
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A geometric method for nipple localization.
[BACKGROUND] An important part of preoperative assessment in breast reduction surgery is to locate the site of the nipple-areola complex for the newly structured breast. Inappropriate location is difficult to correct secondarily. Traditiona…
- Modernizing medical careers in the UK and plastic surgery as a possible career choice: undergraduate opinions.
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Continuous intravenous versus bolus parenteral midazolam: a safe technique for conscious sedation in plastic surgery.
Conscious intravenous sedation is a safe alternative method to general anaesthesia. We have used a technique of continuously titrated, as opposed to incremental boluses of, intravenous or intramuscular midazolam for conscious sedation, with…