논문 목록
7건-
Prognostic nomogram for patients with HER2-negative metastatic gastric cancer receiving first-line PD-1 blockade.
[BACKGROUND] Programmed cell death protein 1 (PD-1) blockade-based therapies have become the new standard for first-line treatment of metastatic gastric cancer (mGC), but a lack of effective prognostic models hinders precise risk stratifica…
-
Large-scale serum N-glycomics tracks N-glycosylation dynamics in hepatocellular carcinoma progression and enables early diagnosis.
Hepatocellular carcinoma (HCC) is a leading cause of cancer mortality, yet the role of N-glycosylation in its pathogenesis remains unclear. We applied a multi-center, large-cohort N-glycomics strategy combining isomer-specific glycan profil…
-
Broadband Nanocavity Imaging with Machine Vision for Multiplex miRNA Assays.
Sensitive and multiplexed quantification of microRNAs (miRNAs) remains challenging due to their short length, low abundance, and sequence homology, particularly in complex biological matrices. This paper presents an approach that combines a…
-
Computed tomography-based artificial intelligence for predicting preoperative microvascular invasion in hepatocellular carcinoma: a systematic review and meta-analysis.
[PURPOSE] This meta-analysis evaluates the diagnostic performance of computed tomography (CT)-based artificial intelligence (AI) models versus radiologists for preoperative microvascular invasion (MVI) detection in hepatocellular carcinoma …
-
Clinically friendly smart hydrogel boosts cuproptosis and PD-L1 upregulation to enhance anti-tumor immunotherapy.
Triple-negative breast cancer (TNBC) faces the challenge of limited treatment efficacy due to its highly invasive ability and its immunosuppressive microenvironment. This study found that cuproptosis, as an emerging therapeutic strategy, ha…
-
GlyTrait: A Versatile Bioinformatics Tool for Glycomics Analysis.
We developed GlyTrait, a Python-based framework designed to enhance Glycomics analysis through the innovative calculation and interpretation of derived traits from -glycome data. Glycomics research often grapples with the interpretability a…
-
tRF-1:30-Gly-CCC-3 inhibits thyroid cancer via binding to PC and modulating metabolic reprogramming.
tRFs and tiRNAs (tRNA-derived fragments) are an emerging class of small noncoding RNAs produced by the precise shearing of tRNAs in response to specific stimuli. They have been reported to regulate the pathological processes of numerous hum…