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Neutrophil- and Platelet-to-Lymphocyte Ratios as Predictive Markers for Capsular Contracture after Immediate Implant-Based Reconstruction.
[BACKGROUND] Capsular contracture remains a significant complication of nipple-sparing mastectomy(NSM) with immediate direct-to-implant(DTI) reconstruction. Although local inflammation is known to contribute to its development, the role of …
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Poly-lactic Acid Dermal Filler Enriched With InCube-encapsulated Vitamin C and Glutathione: Preclinical Evidence of Superior Collagen Induction and Tissue Response Compared With Conventional PLA.
[BACKGROUND/AIM] Poly-Lactic acid (PLA) fillers are widely used for facial and body volume restoration because of their collagen-stimulating properties. However, early inflammation, oxidative stress, and variable long-term remodeling remain…
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Development and Evaluation of an Injectable Acellular Dermal Matrix for Breast Reconstruction.
Breast reconstruction following oncoplastic breast-conserving surgery (OBCS) presents significant challenges, particularly in cases where conventional volume displacement techniques are insufficient. While autologous flaps offer an alternat…
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Oncoplastic breast reconstruction with single-port laparoscopically harvested omental flap: insights from a ten-year tertiary center experience.
[PURPOSE] To evaluate the 10-year functional and oncological outcomes of single-port laparoscopically harvested omental flap (SLOF) for immediate breast reconstruction after breast cancer surgery. The technical feasibility and oncologic saf…
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The impact of the new ESTRO-ACROP target volume delineation guidelines for postmastectomy radiotherapy after implant-based breast reconstruction on breast complications.
The European Society for Radiotherapy and Oncology-Advisory Committee in Radiation Oncology Practice (ESTRO-ACROP) updated a new target volume delineation guideline for postmastectomy radiotherapy (PMRT) after implant-based reconstruction. …
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Assessment of inflammatory suppression and fibroblast infiltration in tissue remodelling by supercritical CO acellular dermal matrix (scADM) utilizing Sprague Dawley models.
Human skin-derived ECM aids cell functions but can trigger immune reactions; therefore it is addressed through decellularization. Acellular dermal matrices (ADMs), known for their regenerative properties, are used in tissue and organ regene…
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The effect of hypotonic pharmacologic lipodissolution on abdominal free flap perfusion: a case report.
[BACKGROUND] Hypotonic pharmacologic lipodissolution (HPL) has gained popularity as a treatment for abdominal fat reduction, especially among Asian individuals. However, research on the effect of HPL on abdominal vascularity and abdominal a…
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Comparative In Vivo Study of Solid-Type Pure Hyaluronic Acid in Thread Form: Safety and Efficacy Compared to Hyaluronic Acid Filler and Polydioxanone Threads.
[INTRODUCTION] Although various products are commonly used for skin rejuvenation, solid-type hyaluronic acid (HA) as an injectable form has not been researched or utilized. This study aimed to demonstrate the safety and efficacy of solid-ty…
- Correction: Comparative In Vivo Study of Solid-Type Pure Hyaluronic Acid in Thread Form: Safety and Efficacy Compared to Hyaluronic Acid Filler and Polydioxanone Threads.
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Bio-characteristics and Efficacy Analysis of Biodegradable Poly Dioxanone Dermal Filler in a Mouse Model and Humans.
[BACKGROUND/AIM] This research investigated the biophysical properties, safety, and efficacy of polydioxanone (PDO) filler compared to poly-L-lactic acid (PLLA), polycaprolactone (PCL), and hyaluronic acid (HA) fillers. In both mouse and hu…
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Anaplastic Large Cell Lymphoma: Molecular Pathogenesis and Treatment.
Anaplastic large cell lymphoma (ALCL) is an uncommon type of non-Hodgkin's lymphoma (NHL), as well as one of the subtypes of T cell lymphoma, accounting for 1 to 3% of non-Hodgkin's lymphomas and around 15% of T cell lymphomas. In 2016, the…
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Assessment of human adipose-derived stem cell on surface-modified silicone implant to reduce capsular contracture formation.
Medical devices made from poly(dimethylsiloxane) (PDMS)-based silicone implants have been broadly used owing to their inert properties, biocompatibility, and low toxicity. However, long-term implantation is usually associated with complicat…
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Micro-textured silicone-based implant fabrication using electrospun fibers as a sacrificial template to suppress fibrous capsule formation.
Conventionally, macro-textured surfaces comprising several hundred micrometer-sized patterns are used to minimize silicone-based breast implant complications, including capsular contracture. However, because of the recent cases of breast im…
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Risk factors for chest wall depression after implant insertion for breast reconstruction: a retrospective quantitative study.
[BACKGROUND] Implant-based reconstruction represents the most common form of breast reconstruction after mastectomy. Although the complication rate has lowered owing to the current advances, various implant-related complications are still a…
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Comparison of Formation of Capsule Among Different Breast Silicone Implants.
[BACKGROUND/AIM] Silicone implants are widely used biomaterials in surgeries owing to their physiological inertness and low toxicity. However, capsular contracture is a severe complication caused by the insertion of breast implants, which c…
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Association of lymphatic flow velocity with surgical outcomes in patients undergoing lymphovenous anastomosis for breast cancer-related lymphedema.
[PURPOSE] Lymphovenous anastomosis (LVA) is primarily used for treating early-stage lymphedema. Here, we aimed to investigate the relationship between lymphatic flow velocity and the efficacy of LVA in breast cancer-related lymphedema patie…
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The effect of immediate postoperative intravenous administration of ferric carboxymaltose after autologous free-flap breast reconstruction.
Intravenous ferric carboxymaltose (IV-FCM) can effectively correct perioperative anemia in patients undergoing major surgeries. However, its efficacy and side effects in patients undergoing free flap-based breast reconstruction are yet to b…
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The Safety of Operating on Breasts With a History of Prior Reduction Mammoplasty: Dynamic Magnetic Resonance Imaging Analysis of Angiogenesis.
[BACKGROUND] The vascularity of the nipple-areolar complex (NAC) is altered after reduction mammoplasty, increasing the risk of complications after repeat reduction or nipple-sparing mastectomy. [OBJECTIVES] The aim of this study was to ev…
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Silicone Breast Implant Coated with Triamcinolone Inhibited Breast-Implant-Induced Fibrosis in a Porcine Model.
Cosmetic silicone implants for breast reconstruction often lead to medical complications, such as abnormally excessive fibrosis driven by foreign body granulomatous inflammation. The purpose of this study was to develop a silicone breast im…
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Silicone Implants Immobilized with Interleukin-4 Promote the M2 Polarization of Macrophages and Inhibit the Formation of Fibrous Capsules.
Breast augmentations with silicone implants can have adverse effects on tissues that, in turn, lead to capsular contracture (CC). One of the potential ways of overcoming CC is to control the implant/host interaction using immunomodulatory a…
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Functionalization of Silicone Surface with Drugs and Polymers for Regulation of Capsular Contracture.
Breast reconstruction is achieved using silicone implants, which are currently associated with major complications. Several strategies have been considered to overcome the existing limitations as well as to improve their performance. Recent…
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Efficacy study of the new polycaprolactone thread compared with other commercialized threads in a murine model.
[BACKGROUND] Polydioxanone (PDO) threads, poly-L-lactic acid (PLLA) threads, and polycaprolactone (PCL) threads have been used for lifting and antiaging purposes. The new PCL threads that have less residual monomer compared to the previous …
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Retrospective multicenter cohort analysis of 621 cases of BellaGel silicone breast implants with study of physicochemical properties and surface topography.
This study aimed to assess the effectiveness and safety of BellaGel implants after implantation in Asian women and inform surgeons of another option for use in breast augmentation and reconstruction. This study was conducted in eight hospit…
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BellaGel breast implant: 6-Year results of a prospective cohort study.
[BACKGROUND] This is the first clinical study conducted among Asian women using breast implants manufactured by an Asian company. Four-year data regarding the safety and efficacy of BellaGel breast implants have already been published, and …
- A compound osteocartilaginous graft with polycaprolactone (PCL) mesh in Asian rhinoplasty.
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Modulation of Foreign Body Reaction against PDMS Implant by Grafting Topographically Different Poly(acrylic acid) Micropatterns.
The surface of poly(dimethylsiloxane) (PDMS) is grafted with poly(acrylic acid) (PAA) layers via surface-initiated photopolymerization to suppress the capsular contracture resulting from a foreign body reaction. Owing to the nature of photo…
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Finite element analysis of long-term changes of the breast after augmentation mammoplasty: Implications for implant design.
The development of breast implant technology continues to evolve over time, but changes in breast shape after implantation have not been fully elucidated. Thus, we performed computerized finite element analysis in order to better understand…
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BellaGel breast implant: 4-year results of a prospective cohort study.
The demand for high-quality silicone breast implants is rising. This was the first clinical study on implantation of Asian company-made silicone breast implants into Asian women. The authors report 4-year study data for BellaGel implants. T…
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Current Approaches Including Novel Nano/Microtechniques to Reduce Silicone Implant-Induced Contracture with Adverse Immune Responses.
Capsular contracture, which is the pathologic development of fibrous capsules around implants, is a major complication of reconstructive and aesthetic breast surgeries. Capsular contracture can cause implant failure with breast hardening, d…
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Dual surface modification of PDMS-based silicone implants to suppress capsular contracture.
[UNLABELLED] In this study, we report a new physicochemical surface on poly(dimethylsiloxane) (PDMS)-based silicone implants in an effort to minimize capsular contracture. Two different surface modification strategies, namely, microtexturin…