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Development of Teleoperated Robotic System for Remote Intraocular Microsurgery.
Microsurgery has revolutionized modern surgery through its precision and favorable outcomes, but it remains limited by operational difficulty and the scarcity of skilled surgeons. Advances in robotics and communication technology have enabl…
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MEFA-Unet: Multi-scale feature extraction and fusion attentional unet for segmenting short process of incus in otologic microsurgical scenarios.
[BACKGROUND] The application of convolutional neural networks (CNNs) in microsurgery has been limited. Current CNNs struggle to capture diverse semantic details across various scales and receptive fields, and they also face challenges in es…
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Efficacy, Influencing Factors and Prediction Models of Type A Botulinum Toxin in Treating Glabellar Lines.
[BACKGROUND] Botulinum Toxin Type A (BoNT/A) injection for glabellar lines is popular due to its minimally invasive nature, safety, and efficacy. However, injection techniques and factors influencing outcomes need further study. This study …
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Endothelial TBK1 Deficiency Inhibits Endothelial-to-Mesenchymal Transition and Atherogenesis Through Suppressing PAK1/ERK1/2 Signaling.
[BACKGROUND] Atherosclerotic vascular diseases remain the leading cause of death despite the use of lipid-lowering drugs. The development of more efficacious therapies targeting endothelial inflammation and endothelial-to-mesenchymal transi…
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Botulinum Toxin Type A in the Treatment of Primary Axillary Hyperhidrosis:A Phase 3, Multicenter, Randomized, Double-Blind, Placebo-Controlled Study of Efficacy and Safety in Chinese Patients.
[BACKGROUND] The efficacy and safety of botulinum toxin type A (BoNTA) treatment for primary axillary hyperhidrosis (PAH) have not been explored in the Chinese population. [OBJECTIVES] The objective was to evaluate efficacy and safety of 1…
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Automated facial nerve identification in microsurgery with an improved unet.
To develop a deep-learning model that improves the segmentation and detection of Facial Nerve in microsurgery, thereby increasing surgical precision and safety. We collected videos from 25 patients undergoing facial nerve decompression micr…
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Impact of anterior commissure invasion on the oncological efficacy of transoral laser microsurgery for T1 glottic cancer.
[BACKGROUND] In glottic laryngeal cancer, anterior commissure (AC) involvement affects prognosis. T staging ignores AC subregion involvement and TNM staging may not suit as an AC prognostic indicator. We explored how AC involvement degree i…
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Feasibility and Clinical Efficacy of Minimally Invasive Straight-Incision Endodontic Microsurgery Guided by 3-Dimensional Printed Templates: A Retrospective Case Series.
[INTRODUCTION] Endodontic microsurgery (EMS) is a minimally invasive treatment for persistent periapical lesions. This study evaluates the accuracy and outcomes of a straight-incision EMS guided by 3-dimensional (3D)-printed template, with …
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Leveraging AAV1-Rac1T17N to prevent experimental proliferative vitreoretinopathy.
[BACKGROUND] Platelet-derived growth factor receptor β (PDGFRβ) is the principal PDGFR isoform in retinal pigment epithelial (RPE) cells from the epiretinal membranes of patients with proliferative vitreoretinopathy (PVR). Ras-related C3 Bo…
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Efficiency and Safety of Noninvasive and Intravesical Therapy for Adult Neurogenic Lower Urinary Tract Dysfunction: A Systematic Review and Network Meta-analysis of Randomized Controlled Trials.
[BACKGROUND] Neurogenic lower urinary tract dysfunction (NLUTD), a complex abnormality caused by multiple neurologic disorders, is a serious threat to patients' prognosis and quality of life. However, benefit and safety for various treatmen…
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Botulinum Toxin Type A Inhibits Submandibular Secretion via the ERK/miR-124-3p/Specificity Protein 1/Claudin-1 Axis.
Botulinum toxin type A (BTXA) is widely used for the treatment of sialorrhea; however, its mechanism remains unclear. Tight junctions (TJs) are limiting factors for salivary secretion through the paracellular pathway in the salivary gland, …
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Real-world large sample evaluation of drug-related blepharoptosis: a pharmacovigilance analysis of the FDA Adverse Event Reporting System database.
[BACKGROUND] Blepharoptosis is one of the most common eyelid disorders in clinical ophthalmology. Previous evidence on drug-related blepharoptosis limited to case reports. [OBJECTIVES] This study aims to systematically evaluate the disprop…
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Signal mining of botulinum toxin type A adverse events based on FAERS database and its implications for the treatment of cerebral palsy.
[OBJECTIVE] Based on the US Food and Drug Administration Adverse Event Reporting System (FAERS), signal mining of adverse drug events (AEs) caused by Botulinum Toxin Type A (BoNTA) was performed to explore its safety implications for the tr…
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Comparative complications of prepectoral versus subpectoral breast reconstruction in patients with breast cancer: a meta-analysis.
[INTRODUCTION] This meta-analysis aims to evaluate the complications associated with prepectoral breast reconstruction (PBR) compared to subpectoral breast reconstruction (SBR) in patients diagnosed with breast cancer. [MATERIALS AND METHO…
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Transfer learning for anatomical structure segmentation in otorhinolaryngology microsurgery.
[BACKGROUND] Reducing the annotation burden is an active and meaningful area of artificial intelligence (AI) research. [METHODS] Multiple datasets for the segmentation of two landmarks were constructed based on 41 257 labelled images and 6…
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Treating rosacea with botulism toxin: Protocol for a systematic review and meta-analysis.
[BACKGROUND] Rosacea is a chronic inflammatory disease usually associated with persistent erythema and periodic flushing. This disease is difficult to treat, and the outcomes are often unsatisfactory and prone to recurrence. In recent years…
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Dissecting and tracing the gut microbiota of infants with botulism: a cross sectional and longitudinal study.
[BACKGROUND] Infant botulism is caused by botulinum neurotoxin (BoNT), which is mainly produced by . However, there is a lack of longitudinal cohort studies on infant botulism. Herein, we have constructed a cross-sectional and longitudinal …
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Incarvine C and its analogues inhibit the formation of cell cytoskeleton by targeting Rac1.
Ras-related C3 botulinum toxin substrate 1 (Rac1) has emerged as a key regulator in the treatment of cancer metastasis because of its involvement in the formation of cell plate pseudopods and effects on cell migration. In this study, we fou…
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NINJ1: A new player in multiple sclerosis pathogenesis and potential therapeutic target.
Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system (CNS) characterized by demyelination. Current treatment options for MS focus on immunosuppression, but their efficacy can be limited. Recent studies sug…
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Comparative analysis of surgical modalities for the gynecomastia treatment: efficiency and aesthetic outcomes.
This retrospective study rigorously compares the clinical efficacy of three surgical methodologies for treating gynecomastia while providing guidance for future surgical modality selection. We analyzed records of 77 gynecomastia patients tr…
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Intramuscular Microvascular Flow Sensing for Flap Monitoring in a Porcine Model of Arterial and Venous Occlusion.
[BACKGROUND] Commercially available near infrared spectroscopy devices for continuous free flap tissue oxygenation (StO) monitoring can only be used on flaps with a cutaneous component. Additionally, differences in skin quality and pigment…
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[Curative effects of bi-pedicled deep inferior epigastric perforator flap in repairing large soft tissue defects in the lower limbs].
To investigate the curative effects of bi-pedicled deep inferior epigastric perforator (DIEP) flap in repairing large soft tissue defects in the lower limbs. A retrospective observational study was conducted. From February 2016 to June 202…
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PseudoSegRT: efficient pseudo-labelling for intraoperative OCT segmentation.
[PURPOSE] Robotic ophthalmic microsurgery has significant potential to help improve the success of challenging procedures and overcome the physical limitations of the surgeon. Intraoperative optical coherence tomography (iOCT) has been repo…
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Microsurgical Treatment of Arteriovenous Malformations: A Single-Center Study Experience.
[OBJECTIVE] The purpose of the study was to assess the functional outcomes after microsurgical resection of arteriovenous malformations (AVMs) and to compare the results between patients eligible for A Randomized Trial of Unruptured Brain A…
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Botulinum toxin in the treatment of sialorrhea in severe neurological patients with tracheotomy.
[OBJECTIVE] To observe the clinical effect of botulinum toxin type A (BTA) injection into the salivary glands of the severe neurological patients with tracheotomy METHODS: Seven patients with severe neurological disorders after tracheotomy …
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[Rac1 promotes the formation of heterotypic cell-in-cell structure].
Heterotypic cell-in-cell structures (heCICs) are closely related to tumor development and progression, and have become a new frontier in life science research. Ras-related C3 botulinum toxin substrate 1 (Rac1) belongs to the classic Rho GTP…
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Ultrasound-guided Serratus Anterior Plane Block, Along with Improved Parasternal Block, is Superior to Serratus Anterior Plane Block Alone in Relieving Pain for Rhinoplasty with Autologous Costal Cartilage.
[BACKGROUND] Rhinoplasty with autologous costal cartilage (ACC) is followed by severe pain in the chest. Ultrasound-guided (USG) serratus anterior plane block (SAPB), in combination with parasternal block (PSB), was earlier reported to be h…
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Use of Remimazolam Combined With Alfentanil for Plastic Surgery Anesthesia Cases: A Clinical Trial.
[OBJECTIVE] This study aims to observe the safety and effectiveness of remimazolam benzenesulfonate combined with alfentanil for painless and comfort anesthesia in plastic surgery. [METHODS] Two hundred patients with American Society of An…
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Implantable, wireless, self-fixing thermal sensors for continuous measurements of microvascular blood flow in flaps and organ grafts.
Vascular pedicle thrombosis after free flap transfer or solid organ transplantation surgeries can lead to flap necrosis, organ loss requiring re-transplantation, or even death. Although implantable flow sensors can provide early warning of …
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Organ preservation surgery for pyriform sinus carcinoma with vocal cord fixation: functional and oncological outcomes.
[BACKGROUND] Pyriform sinus carcinoma with vocal cord fixation is stratified as stage T3 and above, and non-surgical treatment is generally preferred according to the guidelines, aiming to preserve laryngeal function. However, long-term sur…