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PODXL2 maintains cellular stemness and promotes breast cancer development through the Rac1/Akt pathway.
The cluster of differentiation 34 (CD34) family, which includes CD34, podocalyxin-like protein 1 (PODXL), and PODXL2, are type-I transmembrane sialomucins and markers of hematopoietic stem cells (HSCs) and vascular-associated tissues. CD34 …
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Single-cell RNA sequencing reveals gene expression signatures of breast cancer-associated endothelial cells.
Tumor endothelial cells (TEC) play an indispensible role in tumor growth and metastasis although much of the detailed mechanism still remains elusive. In this study we characterized and compared the global gene expression profiles of TECs a…