논문 목록
26건 · 최신순-
Efficacy of Modified Antegrade Digital Artery-Nerve V-Y Island Flap and Bilateral Neurovascular Bundle-Bearing V-Y Island Flap in Repairing Distal Fingertip Defects: A Comparative Analysis.
[AIM] Fingertip defects are common injuries in hand surgery, and their functional reconstruction remains a clinical challenge. This study aims to compare the clinical efficacy of the modified antegrade digital artery-nerve V-Y island flap w…
-
Current landscape and challenges in autologous breast reconstruction across China: A nationwide questionnaire-based survey of 198 hospitals.
[INTRODUCTION] Autologous breast reconstruction (ABR) provides distinct aesthetic and functional advantages; however, its adoption in China remains relatively limited. This nationwide survey evaluated the current status, trends and institut…
-
A prospective study of hair transplantation combined with concentrated growth factors for the treatment of androgenetic alopecia.
[BACKGROUND] Androgenetic alopecia (AGA) is the most common form of hair loss, marked by progressive shedding and follicular miniaturization, with advanced stages leading to irreversible follicular loss. Follicular Unit Extraction (FUE) pro…
-
Protocol for a multicentre, prospective, open-label, randomised controlled trial to compare PROs and safety outcomes between preoperative and postmastectomy radiotherapy in locally advanced breast cancer patients with immediate reconstruction via a deep inferior epigastric perforator flap (CAPPELLA) in China.
[INTRODUCTION] Despite its therapeutic advantages, postmastectomy radiotherapy (PMRT) increases the risk of complications and often leads to poor cosmesis in women undergoing breast reconstruction. Preoperative radiotherapy followed by skin…
-
Construction of osteoporosis diagnosis model based on bioinformatics analysis of autophagy-related genes.
Osteoporosis (OP) is a major health issue that poses a substantial challenge to public health worldwide. In recent decades, knowledge about the etiological mechanisms of osteoporosis has emphasized that bone cell homeostasis is tightly regu…
-
Efficacy and safety of combination of frankincense and botulinum toxin in the treatment of blepharospasm: a protocol for a single-centre, open-label, randomized, controlled trial.
[INTRODUCTION] Blepharospasm (BSP) is a functionally disabling disease with a marked impact on the quality of life of patients. Botulinum toxin (BoNT) injections have been recommended as first-line therapy for BSP. However, the clinical ben…
-
A Rat Model of Pouchitis Following Proctocolectomy and Ileal Pouch-Anal Anastomosis Using Dextran Sulfate Sodium.
Ulcerative colitis (UC) is a chronic immune-mediated disease that affects the entire colon and rectum with a relapsing and remitting course, causing lifelong morbidity. When medical treatment is ineffective, especially in cases of massive g…
-
The Efficacy of Magnesium Sulfate (MgSO4) Wet Dressing in Reducing Eyelid Swelling and Bruising after Blepharoplasty: A Randomized, Controlled, and Observer-Blinded Assessment Study.
The purpose of this study was to evaluate the effects of wet dressing with 50% magnesium sulfate (MgSO) solution on decreasing eyelid swelling and bruising after blepharoplasty. Fifty-eight patients (23 male and 35 female) who underwent bil…
-
A comparative study of three-dimensional airway changes after fibula flap reconstruction for benign and malignant tumours in the anterior mandible.
Surgical treatment of tumours in the anterior mandible and surrounding tissues may result in defects which can be restored by a fibula free flap. The upper airway may change during this process. The purpose of this retrospective study was t…
-
Effects of spermine on the proliferation and migration of porcine intestinal epithelial cells.
Whether spermine promotes the repair of porcine intestinal epithelium damage through Ras-related C3 botulinum toxin substrate 1 (Rac1)/phospholipase C-γ1 (PLC-γ1) signaling remains unclear. The current study investigated the effects of sper…
-
Calcium-sensing receptor protects intestinal integrity and alleviates the inflammatory response via the Rac1/PLCγ1 signaling pathway.
This study aimed to test the hypothesis that the calcium-sensing receptor (CaSR) can protect intestinal epithelial barrier integrity and decrease inflammatory response mediated by the Ras-related C3 botulinum toxin substrate 1 (Rac1)/phosph…
-
β-hydroxybutyrate impairs the directionality of migrating neutrophils through inhibiting the autophagy-dependent degradation of Cdc42 and Rac1 in ketotic cows.
Dairy cows have high incidence of ketosis during perinatal. According to our previous studies, elevated ketone bodies (mainly β-hydroxybutyrate, BHB) in the peripheral blood are believed to contribute to the impairment of neutrophils mobili…
-
The Efficacy and Safety of Botulinum Toxin Type A Injections in Improving Facial Scars: A Systematic Review and Meta-Analysis.
[BACKGROUND] Botulinum toxin type A (BTA) has a wide range of clinical applications, and its use in improving aesthetics is one of them. The aim of this study was to better assess the efficacy and safety of BTA in patients with facial scars…
-
Spermine protects intestinal barrier integrity through ras-related C3 botulinum toxin substrate 1/phospholipase C-γ1 signaling pathway in piglets.
Weaning stress can cause tight junctions damage and intestinal permeability enhancement, which leads to intestinal imbalance and growth retardation, thereby causing damage to piglet growth and development. Spermine can reduce stress. Howeve…
-
Tryptophan improves porcine intestinal epithelial cell restitution through the CaSR/Rac1/PLC-γ1 signaling pathway.
This study aimed to investigate the effect of tryptophan on cell migration and its underlying mechanism in porcine intestine epithelial cells (IPEC-J2). This study shows that tryptophan can modulate IPEC-J2 cell proliferation, enhance cell …
-
Tryptophan Ameliorates Barrier Integrity and Alleviates the Inflammatory Response to Enterotoxigenic K88 Through the CaSR/Rac1/PLC-γ1 Signaling Pathway in Porcine Intestinal Epithelial Cells.
[BACKGROUND] Impaired intestinal barrier integrity plays a crucial role in the development of many diseases such as obesity, inflammatory bowel disease, and type 2 diabetes. Thus, protecting the intestinal barrier from pathological disrupti…
-
Adipose-derived mesenchymal stem cell exosomes inhibit transforming growth factor-β1-induced collagen synthesis in oral mucosal fibroblasts.
Oral submucosal fibrosis (OSF) is a potentially malignant oral disorder that requires the further development of advanced treatment strategies. TGF-β1 has been reported to be the main trigger for the increased collagen production and reduce…
-
Proximal Tibial Cortex Transverse Distraction Facilitating Healing and Limb Salvage in Severe and Recalcitrant Diabetic Foot Ulcers.
[BACKGROUND] The management of severe and recalcitrant diabetic foot ulcers is challenging. Distraction osteogenesis is accompanied by vascularization and regeneration of the surrounding tissues. Longitudinal distraction of the proximal tib…
-
[Local injection of BTX-A prevents iatrogenic anterior urethral stricture in rabbits].
[OBJECTIVE] To investigate the preventive effect of local injection of botulinum toxin type A (BTX-A) against iatrogenic anterior urethral stricture (IAUS) in New Zealand male rabbits. [METHODS] Sixteen adult New Zealand male rabbits were …
-
Subcutaneous Fat in the Upper Eyelids of Asians: Application to Blepharoplasty.
The Asian eyelid has distinctive anatomical properties. Although the upper eyelid is reported in the literature to have no subcutaneous fat layer, we have often noticed adipose tissue below the upper eyelid skin during ophthalmic plastic su…
-
Influence of Recipient Site on the Function and Survival of Fat Grafts.
[BACKGROUND] Autologous fat grafting has become an increasingly common procedure for soft tissue augmentation throughout the body. However, the long-term outcome is always unpredictable because of inconsistent graft survival. Based on the "…
-
Spliced leader-based analyses reveal the effects of polycyclic aromatic hydrocarbons on gene expression in the copepod Pseudodiaptomus poplesia.
Polycyclic aromatic hydrocarbons (PAHs) are a group of toxic and carcinogenic pollutants that can adversely affect the development, growth and reproduction of marine organisms including copepods. However, knowledge on the molecular mechanis…
-
Development of orbital adipose-derived stem cells as a model for studying the formation of baggy lower eyelids.
In old population, there is often a protrusion of the orbital fat pad underlying the skin in the lower eyelids, giving an aspect of palpable pouches. It is generally thought that orbital fat hyperplasia is the main contributing factor to th…
-
Up-regulation of Orai1 expression and store operated Ca(2+) entry following activation of membrane androgen receptors in MCF-7 breast tumor cells.
[BACKGROUND] Membrane androgen receptors (mAR) are functionally expressed in a variety of tumor-cells including the breast tumor-cell line MCF-7. They are specifically activated by testosterone albumin conjugates (TAC). The mAR sensitive si…
-
Histocompatibility and long-term results of the follicular unit-like wigs after xenogeneic hair transplantation: an experimental study in rabbits.
Objective. This study was designed to observe the histocompatibility and long-term results of wigs after xenogeneic hair transplantation and to explore the possibility of industrial products in clinical application. Methods. The human hair …
-
Immunocytochemical localization of sex steroid hormone receptors in normal human mammary gland.
The sex steroids, estrogens, progesterone, and androgens, all play a role in mammary development and function. To precisely identify the sites of action of these steroids, we studied the localization of the estrogen receptor alpha (ERalpha)…