A prospective study of hair transplantation combined with concentrated growth factors for the treatment of androgenetic alopecia.

[BACKGROUND] Androgenetic alopecia (AGA) is the most common form of hair loss, marked by progressive shedding and follicular miniaturization, with advanced stages leading to irreversible follicular loss. Follicular Unit Extraction (FUE) provides favorable outcomes even in patients with reduced follicular density. Concentrated Growth Factors (CGF), a third-generation platelet concentrate rich in growth factors (GFs), may enhance follicular survival, promote growth, and improve density with good safety, yet evidence supporting its combined use with FUE remains limited.

[OBJECTIVE] This study aims to conduct a prospective clinical comparative trial to evaluate the synergistic effect of CGF when used in conjunction with FUE for the treatment of AGA.

[METHOD] This study randomized 26 male AGA patients (2022-2024) to receive FUE alone or with CGF injections. Efficacy was assessed hair density, terminal hair ratio, standardized images, and patient/investigator GAIS satisfaction. Safety was evaluated through adverse event monitoring.

[RESULTS] Baseline characteristics were comparable. At nine months, the experimental group showed significantly higher hair density and a greater increase in terminal hair proportion than the control group ( < 0.05).

[CONCLUSION] CGF-assisted FUE significantly improved hair density and terminal hair ratio compared with FUE alone, with favorable safety and high patient satisfaction.