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206건 · 최신순-
mTORC2/Rac1 Pathway Predisposes Cancer Aggressiveness in Mutated Glioma.
Isocitrate dehydrogenase () mutations are common genetic abnormalities in lower grade gliomas. The neomorphic enzyme activity of IDH mutants leads to tumor formation through epigenetic alteration, dysfunction of dioxygenases, and metabolic …
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DaxibotulinumtoxinA for Injection has a prolonged duration of response in the treatment of glabellar lines: Pooled data from two multicenter, randomized, double-blind, placebo-controlled, phase 3 studies (SAKURA 1 and SAKURA 2).
[BACKGROUND] DaxibotulinumtoxinA for Injection (DAXI) is a novel botulinum toxin type A in clinical development. Phase 2 data have shown it offers a more prolonged duration of response than onabotulinumtoxinA. [OBJECTIVE] To further evalua…
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Botulinum Toxin Type A for Upper Limb Spasticity in Poststroke Patients: A Meta-analysis of Randomized Controlled Trials.
[BACKGROUND AND AIM] Botulinum toxin type A is considered to be an effective antispasmodic in recent years. We assess the effectiveness of botulinum toxin type A for the treatment of poststroke spasticity in the upper extremity using a meta…
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Paradoxical bulging of mentalis after botulinum toxin type A injection.
[BACKGROUND] Botulinum toxin type A (BTA) injection is a widely-used procedure to correct cosmetic problems caused by muscular hyperactivity. "Cobblestone chin" refers to the appearance of remarkable chin creases caused by mentalis contract…
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[Clinical analysis and laboratory diagnosis of three cases with infantile botulism caused by type B].
To summarize the clinical characteristics and laboratory diagnostic methods of infant botulism caused by type B. Clinical data of 3 infants with type B botulism who were admitted to Children's Hospital Affiliated to Capital Institute of P…
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The Effects of Botulinum Toxin Injections on Spasticity and Motor Performance in Chronic Stroke with Spastic Hemiplegia.
Spastic muscles are weak muscles. It is known that muscle weakness is linked to poor motor performance. Botulinum neurotoxin (BoNT) injections are considered as the first-line treatment for focal spasticity. The purpose of this study was to…
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A novel compound heterozygous mutation in the arginase-1 gene identified in a Chinese patient with argininemia: A case report.
[INTRODUCTION] Arginineemia, also known as arginase deficiency, is a rare autosomal recessive metabolic disease. The diagnosis sometimes may be delayed due to atypical clinical manifestations. Confirmation of arginineemia depends on genetic…
- Fever caused by botulinum toxin injection.
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Botulinum Toxin Injection with Conjunctival Microincision for the Treatment of Acute Acquired Comitant Esotropia and Its Effectiveness.
[PURPOSE] To report on an improved botulinum toxin injection with conjunctival microincision for beginners, and to determine the effectiveness of botulinum toxin A (BTXA) in the treatment of patients with acute acquired comitant esotropia (…
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A novel model for designing and performing parietal whorl hair transplantation.
[BACKGROUND] Hair transplantation is the gold standard method for the treatment of alopecia. Recently, demand for the surgery has increased rapidly. However, high demands also require more professional training for the surgeons. With the ma…
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Divided Eyelid Nevus: Surgical Repair Discussion and Case Reports From Northwestern China.
Currently, due to the lack of long-term postoperative follow-up outcomes of the congenital divided eyelid nevus, we described our surgical approaches and presented the functional and cosmetic results of 13 patients with an average of 5-year…
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[Lay emphasis on the cosmetic repair of donor site].
Skin graft and flap are common tools for wound repair, but donor site would be damaged when harvesting skin graft or flap. If donor site treatment is ignored, various problems concerning the appearance and function of donor site will appear…
- [Thoughts on the application of plastic surgical techniques to phallus surgery of andrology].
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Three dimensional innervation zone imaging in spastic muscles of stroke survivors.
[OBJECTIVE] The outcome of botulinum toxin (BTX) therapy of post-stroke spasticity relies largely on accuracy of BTX injection to the proximity of innervation zones (IZs). Recently developed three-dimensional IZ imaging (3DIZI) is the only …
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Inhibition of lncRNA TUG1 upregulates miR-142-3p to ameliorate myocardial injury during ischemia and reperfusion via targeting HMGB1- and Rac1-induced autophagy.
[BACKGROUND] Long non-coding RNAs (lncRNAs) play a central role in regulating heart diseases. In the present study, we examined the effects of lncRNA taurine up-regulated gene 1 (TUG1) in ischemia/reperfusion (I/R)- or hydrogen peroxide-cha…
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Inhibition of Rac1-dependent forgetting alleviates memory deficits in animal models of Alzheimer's disease.
Accelerated forgetting has been identified as a feature of Alzheimer's disease (AD), but the therapeutic efficacy of the manipulation of biological mechanisms of forgetting has not been assessed in AD animal models. Ras-related C3 botulinum…
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Evaluating the Satisfaction of Patients Undergoing Hair Transplantation Surgery Using the FACE-Q Scales.
[BACKGROUND] It is necessary to evaluate a successful cosmetic procedure from the patients' perspective. FACE-Q is a patient-reported outcome scale for patients undergoing cosmetic procedures. However, currently there are no FACE-Q scales u…
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The relationship between self-esteem and hair transplantation satisfaction in male androgenetic alopecia patients.
[BACKGROUND] Frustrated with the embarrassing appearance, patients with androgenetic alopecia (AGA) suffer from poor quality of life and low self-esteem. Moreover, several researches indicate that self-esteem is an important factor affectin…
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[Application of modified inferior pedicle technique with inverted T pattern for severe breast hypertrophy].
[OBJECTIVE] To explore the effectiveness of modified inferior pedicle technique with inverted T pattern for severe breast hypertrophy. [METHODS] Between January 2016 and May 2017, 15 patients of severe breast hypertrophy had undergone brea…
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Functional/Aesthetic Measures of Patient Satisfaction After Rhinoplasty: A Review.
Multiple patient-reported outcome measures (PROMs) are available to assess patient satisfaction after rhinoplasty. These self-assessment measures can be divided into 3 categories: measures for functional outcomes, aesthetic outcomes, and bo…
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Progress in the Diagnosis and Management of Chorea-acanthocytosis.
Chorea-acanthocytosis (ChAc) is the most common subtype of neuroacanthocytosis syndrome, characterized by the presence of acanthocytes and neurological disorders. It is thought to be caused by VPS13A mutations. Characteristic movement disor…
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Dock2 in the development of inflammation and cancer.
An atypical guanine exchange factor, Dock2 is specifically expressed in hematopoietic cells and regulates activation and migration of immune cells through activating Ras-related C3 botulinum toxin substrate (Rac). Dock2 was shown to be crit…
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MicroRNA-650 targets inhibitor of growth 4 to promote colorectal cancer progression via mitogen activated protein kinase signaling.
Colorectal cancer (CRC) is the third most common malignant disease globally and causes numerous cancer-associated mortalities; however, the underlying molecular mechanisms remain unresolved. MicroRNAs (miRs) are endogenous noncoding RNAs th…
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Clinical analysis of 86 botulism cases caused by cosmetic injection of botulinum toxin (BoNT).
This study was conducted to analyze the clinical characteristics of and treatment strategies for botulism among patients receiving cosmetic injection of botulinum toxin (BoNT).A total of 86 botulism patients caused by cosmetic injection of …
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Endothelial Mitochondrial Preprotein Translocase Tomm7-Rac1 Signaling Axis Dominates Cerebrovascular Network Homeostasis.
Objective- Mitochondria are the important yet most underutilized target for cardio-cerebrovascular function integrity and disorders. The Tom (translocases of outer membrane) complex are the critical determinant of mitochondrial homeostasis …
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Efficacy and Safety of Botulinum Toxin Type A in Spasticity Caused by Spinal Cord Injury: A Randomized, Controlled Trial.
BACKGROUND Baclofen is approved by the US FDA to treat spasticity, but its sustained use may cause drug addiction. The objective of this study was to compare the efficacy and safety of botulinum toxin type A versus baclofen in spasticity. M…
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Botulinum Toxin A Plays an Important Role in the Placement of Implants Deep Within the Pectoralis Major Muscle for Mammaplasty: A Systematic Review and Meta-analysis.
[BACKGROUND] Breast prosthesis implants have been safely and efficiently used in the plastic surgery department. With the increasing demand for aesthetics, these silicon implants were not only used in breast augmentation surgery but also in…
- Reply: Evaluation of Preoperative and Postoperative Patient Satisfaction and Quality of Life in Patients Undergoing Rhinoplasty: A Systematic Review and Meta-Analysis.
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Evaluation of Preoperative and Postoperative Patient Satisfaction and Quality of Life in Patients Undergoing Rhinoplasty: A Systematic Review and Meta-Analysis.
[BACKGROUND] Improvement of nasal aesthetics by means of rhinoplasty is a highly sought-after procedure and leads to increased patient confidence. The aim of the study was to provide a quantitative synthesis of existing data regarding the a…
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[Review of sixty years of burn discipline in Shanghai Ruijin Hospital].
Department of Burns and Plastic Surgery of Ruijin Hospital Affiliated to the Medical School of Shanghai Jiao Tong University is derived from the group of severe burn treatment in Surgical Department of Kuang-Ci Hospital in Shanghai in 1958.…