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Paralemmin-1 is over-expressed in estrogen-receptor positive breast cancers.
[BACKGROUND] Paralemmin-1 is a phosphoprotein lipid-anchored to the cytoplasmic face of membranes where it functions in membrane dynamics, maintenance of cell shape, and process formation. Expression of paralemmin-1 and its major splice var…
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Use of an aggressive MCF-7 cell line variant, TMX2-28, to study cell invasion in breast cancer.
An estrogen receptor-negative variant of the MCF-7 breast cancer cell line, TMX2-28, was used as a model in which to study breast cancer cell invasion. Using a reconstituted basement membrane (Matrigel) assay to evaluate cell invasion, we d…