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Inter-Individual Variation in Response to Estrogen in Human Breast Explants.
Exposure to estrogen is strongly associated with increased breast cancer risk. While all women are exposed to estrogen, only 12% are expected to develop breast cancer during their lifetime. These women may be more sensitive to estrogen, as …
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DNA methylation in paired breast epithelial and white blood cells from women undergoing reduction mammoplasty.
[BACKGROUND] The extent to which white blood cell (WBC) DNA methylation provides information on the status of breast epithelial cell DNA is unknown. [PATIENTS AND METHODS] We examined the correlation between methylation in Ras-association …
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SKP2 overexpression is associated with increased serine 10 phosphorylation of p27 (pSer10p27) in triple-negative breast cancer.
S-phase kinase-associated protein 2 (SKP2) is an important cell cycle regulator, targeting the cyclin-dependent kinase (CDK) inhibitor p27 for degradation, and is frequently overexpressed in breast cancer. p27 regulates G1 /S transition by …
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Paralemmin-1 is over-expressed in estrogen-receptor positive breast cancers.
[BACKGROUND] Paralemmin-1 is a phosphoprotein lipid-anchored to the cytoplasmic face of membranes where it functions in membrane dynamics, maintenance of cell shape, and process formation. Expression of paralemmin-1 and its major splice var…
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Use of an aggressive MCF-7 cell line variant, TMX2-28, to study cell invasion in breast cancer.
An estrogen receptor-negative variant of the MCF-7 breast cancer cell line, TMX2-28, was used as a model in which to study breast cancer cell invasion. Using a reconstituted basement membrane (Matrigel) assay to evaluate cell invasion, we d…