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5건 · 최신순-
Inter-Individual Variation in Response to Estrogen in Human Breast Explants.
Exposure to estrogen is strongly associated with increased breast cancer risk. While all women are exposed to estrogen, only 12% are expected to develop breast cancer during their lifetime. These women may be more sensitive to estrogen, as …
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DNA methylation in paired breast epithelial and white blood cells from women undergoing reduction mammoplasty.
[BACKGROUND] The extent to which white blood cell (WBC) DNA methylation provides information on the status of breast epithelial cell DNA is unknown. [PATIENTS AND METHODS] We examined the correlation between methylation in Ras-association …
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Parity-related molecular signatures and breast cancer subtypes by estrogen receptor status.
[INTRODUCTION] Relationships of parity with breast cancer risk are complex. Parity is associated with decreased risk of postmenopausal hormone receptor-positive breast tumors, but may increase risk for basal-like breast cancers and early-on…
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Age-associated gene expression in normal breast tissue mirrors qualitative age-at-incidence patterns for breast cancer.
[BACKGROUND] Age is the strongest breast cancer risk factor, with overall breast cancer risk increasing steadily beginning at approximately 30 years of age. However, while breast cancer risk is lower among younger women, young women's breas…
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Activation of host wound responses in breast cancer microenvironment.
[PURPOSE] Cancer progression is mediated by processes that are also important in wound repair. As a result, cancers have been conceptualized as overhealing wounds or "wounds that do not heal," and gene expression signatures reflective of wo…