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8건 · 최신순-
Inter-Individual Variation in Response to Estrogen in Human Breast Explants.
Exposure to estrogen is strongly associated with increased breast cancer risk. While all women are exposed to estrogen, only 12% are expected to develop breast cancer during their lifetime. These women may be more sensitive to estrogen, as …
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Parity-related molecular signatures and breast cancer subtypes by estrogen receptor status.
[INTRODUCTION] Relationships of parity with breast cancer risk are complex. Parity is associated with decreased risk of postmenopausal hormone receptor-positive breast tumors, but may increase risk for basal-like breast cancers and early-on…
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Role of HGF in epithelial-stromal cell interactions during progression from benign breast disease to ductal carcinoma in situ.
[INTRODUCTION] Basal-like and luminal breast cancers have distinct stromal-epithelial interactions, which play a role in progression to invasive cancer. However, little is known about how stromal-epithelial interactions evolve in benign and…
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Longitudinal study of mammary epithelial and fibroblast co-cultures using optical coherence tomography reveals morphological hallmarks of pre-malignancy.
The human mammary gland is a complex and heterogeneous organ, where the interactions between mammary epithelial cells (MEC) and stromal fibroblasts are known to regulate normal biology and tumorigenesis. We aimed to longitudinally evaluate …
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Normal breast tissue of obese women is enriched for macrophage markers and macrophage-associated gene expression.
Activation of inflammatory pathways is one plausible mechanism underlying the association between obesity and increased breast cancer risk. However, macrophage infiltration and local biomarkers of inflammation in breast adipose tissue have …
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Age-associated gene expression in normal breast tissue mirrors qualitative age-at-incidence patterns for breast cancer.
[BACKGROUND] Age is the strongest breast cancer risk factor, with overall breast cancer risk increasing steadily beginning at approximately 30 years of age. However, while breast cancer risk is lower among younger women, young women's breas…
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Gene expression profiles of breast biopsies from healthy women identify a group with claudin-low features.
[BACKGROUND] Increased understanding of the variability in normal breast biology will enable us to identify mechanisms of breast cancer initiation and the origin of different subtypes, and to better predict breast cancer risk. [METHODS] Ge…
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Activation of host wound responses in breast cancer microenvironment.
[PURPOSE] Cancer progression is mediated by processes that are also important in wound repair. As a result, cancers have been conceptualized as overhealing wounds or "wounds that do not heal," and gene expression signatures reflective of wo…