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Role of HGF in epithelial-stromal cell interactions during progression from benign breast disease to ductal carcinoma in situ.
[INTRODUCTION] Basal-like and luminal breast cancers have distinct stromal-epithelial interactions, which play a role in progression to invasive cancer. However, little is known about how stromal-epithelial interactions evolve in benign and…
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Normal breast tissue of obese women is enriched for macrophage markers and macrophage-associated gene expression.
Activation of inflammatory pathways is one plausible mechanism underlying the association between obesity and increased breast cancer risk. However, macrophage infiltration and local biomarkers of inflammation in breast adipose tissue have …