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Normal breast tissue of obese women is enriched for macrophage markers and macrophage-associated gene expression.
Activation of inflammatory pathways is one plausible mechanism underlying the association between obesity and increased breast cancer risk. However, macrophage infiltration and local biomarkers of inflammation in breast adipose tissue have …
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Age-associated gene expression in normal breast tissue mirrors qualitative age-at-incidence patterns for breast cancer.
[BACKGROUND] Age is the strongest breast cancer risk factor, with overall breast cancer risk increasing steadily beginning at approximately 30 years of age. However, while breast cancer risk is lower among younger women, young women's breas…