Mielke LV

[BACKGROUND] Capsular contracture is a common complication following breast augmentation and reconstruction with implants. Implant rupture is suspected to cause capsular contracture, but the evidence remains limited. [METHODS] This intrapa…

[BACKGROUND] Silicone leakage from breast implants may contribute to fibrosis leading to capsular contracture, yet no standardized method exists to quantify silicone leakage reliably. [OBJECTIVES] To validate a histological method for quan…

[BACKGROUND] Capsular contracture is a common complication following breast reconstruction and augmentation, but there is limited evidence for the association between silicone leaking from the implant and capsular contracture. [OBJECTIVES]…

Biomedical implants significantly enhance quality of life for millions of individuals worldwide. However, maintaining long-term implant function remains challenging, and it is often due to a severe foreign body response, characterized by fi…

[BACKGROUND] Understanding the impact of breast implants on the histological response in the surrounding fibrous capsule is important; however, consensus is lacking on how to analyze implant capsules histologically. We aimed to develop a st…

[BACKGROUND] Capsular contracture is traditionally evaluated with the Baker classification, but this has notable limitations regarding reproducibility and objectivity. [OBJECTIVES] The aim of this study was to develop and validate procedur…

[BACKGROUND] Recent clinical studies have documented the analgesic, anti-inflammatory, antioxidative and anxiolytic effects of exogenous melatonin. The pharmacokinetic properties of melatonin have primarily been investigated in experimental…