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Pharmacotherapy and non-invasive neuromodulation for neuropathic pain: a systematic review and meta-analysis.
[BACKGROUND] There remains a substantial unmet need for effective and safe treatments for neuropathic pain. The Neuropathic Pain Special Interest Group aimed to update treatment recommendations, published in 2015, on the basis of new eviden…
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Botulinum Neurotoxin A Signaling in Pain Modulation Within Human Sensory Neurons.
OnabotulinumtoxinA (onabotA), a Botulinum neurotoxin type A (BoNT/A), is an effective treatment for chronic migraine, but its direct mechanism of action on human sensory neurons has not been fully elucidated. While rodent studies on dorsal …
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Anthrax toxins regulate pain signaling and can deliver molecular cargoes into ANTXR2 DRG sensory neurons.
Bacterial products can act on neurons to alter signaling and function. In the present study, we found that dorsal root ganglion (DRG) sensory neurons are enriched for ANTXR2, the high-affinity receptor for anthrax toxins. Anthrax toxins are…