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High-dose Botulinum Toxin Therapy: Safety, Benefit, and Endurance of Efficacy.
[BACKGROUND] Botulinum neurotoxin therapy (BoNT) is a powerful tool for treating many neurologic disorders. The U.S. Food and Drug Administration (FDA)-approved maximum onabotulinum toxin A (OnaA) dose is 400 units (U) per visit, but higher…