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15건 · 최신순-
Neurorehabilitation in Dystonia Care: Key Questions of Who Benefits, What Modalities, and When to Intervene.
Dystonia causes involuntary, patterned movements and posturing, often leading to disability, pain, and reduced quality-of-life. Despite standard treatments such as botulinum toxin (BoNT) injections, oral medications, and deep brain stimulat…
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Is the use of botulinum toxin injection for treating neurological disorders safe during pregnancy and lactation?
Botulinum neurotoxin (BoNT) is a mainstay in treating several neurological disorders including in women of reproductive age. This review, based on 43 studies encompassing 658 human cases and supporting animal data, evaluates its safety duri…
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Basis of movement control in dystonia and why botulinum toxin should influence it?
Dystonia is a network disorder involving multiple brain regions, such as the motor cortex, sensory cortex, basal ganglia, and cerebellum. Botulinum toxin (BoNT) is the first-line therapy for treating focal dystonia and is a potent molecule …
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Case report: Lingual dystonia symptoms treated with botulinum toxin in patients with THAP1 mutation.
[BACKGROUND] THAP1 mutation dystonia is a known genetic cause of generalized dystonia. THAP1 mutation frequently presents with clinical features of bulbar dysfunction, including oromandibular and lingual dystonia. Patients complain of signi…
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Clinical and physiological characteristics of tremor in a large cohort of focal and segmental dystonia.
[OBJECTIVE] Tremor is a frequent co-occurring feature in patients with dystonia, especially in focal and segmental dystonia. Clinical studies have shown that tremor is more commonly observed when dystonia spreads to contiguous body regions.…
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Pain control due to botulinum toxin therapy in cervical dystonia relates to the sensorimotor integration process.
[BACKGROUND] Botulinum toxin (BoNT) injections have been found to improve pain symptoms of isolated cervical dystonia (CD). In addition to muscle relaxation at the peripheral level, few studies suggest that BoNT has effects on the central b…
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Reduction of neuronal hyperexcitability with modulation of T-type calcium channel or SK channel in essential tremor.
Essential tremor is one of the most prevalent movement disorders. Propranolol and primidone are the first-line pharmacological therapies. They provide symptomatic control in less than 50% of patients. Topiramate, alprazolam, clonazepam, gab…
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High-dose Botulinum Toxin Therapy: Safety, Benefit, and Endurance of Efficacy.
[BACKGROUND] Botulinum neurotoxin therapy (BoNT) is a powerful tool for treating many neurologic disorders. The U.S. Food and Drug Administration (FDA)-approved maximum onabotulinum toxin A (OnaA) dose is 400 units (U) per visit, but higher…
- Reply to letter to the editor, "A randomized study of botulinum toxin versus botulinum toxin plus physical therapy for treatment of cervical dystonia.".
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Case Report: Globus Pallidus Internus (GPi) Deep Brain Stimulation Induced Keyboard Typing Dysfunction.
Typing on a keyboard requires complex collaboration between visuospatial/procedural memory, language, and motor function. The impaired ability to type, independent of motor deficits, apraxia, or aphasia has been coined "dystypia." : A 68-ye…
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A randomized study of botulinum toxin versus botulinum toxin plus physical therapy for treatment of cervical dystonia.
[BACKGROUND] Physical therapy (PT) for cervical dystonia is not well studied, and the underlying physiological effects are not known. [METHODS] We enrolled 26 subjects comprising of 16 cervical dystonia and 10 healthy controls for normativ…
- Combined effects of rTMS and botulinum toxin therapy in benign essential blepharospasm.
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Botulinum Toxin Therapy for Parkinson's Disease.
Botulinum toxin (BoNT) therapy is frequently employed in the treatment of Parkinson's disease (PD) symptoms. It can effectively ameliorate the symptoms of cervical dystonia, blepharospasm, sialorrhea, and hyperactive bladder. It is increasi…
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High rates of fatigue and sleep disturbances in dystonia.
[BACKGROUND] Nonmotor symptoms in dystonia are increasingly recognized to impair the quality of life. The primary objective of this study was to determine the prevalence of fatigue and sleep disturbances in dystonia and to ascertain their i…
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Occurrence of Dysphagia Following Botulinum Toxin Injection in Parkinsonism-related Cervical Dystonia: A Retrospective Study.
[BACKGROUND] The aim was to compare the occurrence of post-injection dysphagia in parkinsonism-related cervical dystonia (PRCD) versus cervical dystonia (CD) of other etiologies (non-PRCD). A secondary objective was to explore potential cli…