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ITIH5 inhibits proliferation, adipogenic differentiation, and secretion of inflammatory cytokines of human adipose stem cells-A new key in treating obesity?
Inter-α-trypsin inhibitor heavy chain 5 (ITIH5) is widely expressed in the human body, and it is detected to be particularly abundant in adipose tissue. ITIH5 expression is increased in people with obesity compared to lean persons and is de…
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Comprehensive Analysis of Local Anesthetics Affecting Adipose Stem Cells In Vitro.
[BACKGROUND] Adipose stem cells (ASCs) hold a great regenerative capacity because of their differentiation capability and their secretory activity. Thus, ASC survival is of great significance during perioperative harvesting. Various local a…
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Effects of epinephrine, lidocaine, and prilocaine on viability and differentiation capacity of human adipose stem cells.
[INTRODUCTION] Local anesthetics (LAs) are routinely administered in plastic and reconstructive surgery, e.g., as tumescent anesthesia adjunct in liposuction. Historically, these substances were assumed to act cytotoxically. Thus, the appli…
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Effects of Silicone Breast Implants on Human Cell Types In Vitro: A Closer Look on Host and Implant.
[BACKGROUND] Silicone (gel) breast implants (SBI) are used world-wide for breast augmentation, and reconstruction or to correct breast deformities. They consist of two compounds: an elastomer silicone shell (envelope) and a silicone gel fil…