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Contemporary Indications and Technical Limits of Transoral Laser Microsurgery for Laryngeal Squamous Cell Carcinoma.
Transoral laser microsurgery (TOLMS) is an established organ-preserving treatment for early-stage and selected intermediate-stage laryngeal squamous cell carcinoma (SCC). Initially indicated for Tis-T1 lesions, its use has progressively exp…
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Good and bad indications for adjuvant radiotherapy after transoral laser microsurgery for laryngeal cancer.
[PURPOSE OF REVIEW] To summarize current evidence regarding the indication of adjuvant treatment after transoral laser microsurgery (TOLMS). [RECENT FINDINGS] Apart from well known risk factors, margins represent the key point in the decis…
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Sex differences in laryngeal cancer treated with COtransoral laser microsurgery: a case-control study.
[BACKGROUND] The aim of the present study was to evaluate the sex-disparities in larynx cancer patients treated with COTransoral Laser Microsurgery (CO-TOLMS). [METHODS] Retrospective analysis of 1290 consecutive patients. Oncologic and fu…
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Refining prognostic subcategories in intermediate-advanced glottic cancer: A multicentric study on 637 patients treated by transoral laser microsurgery.
[BACKGROUND] The current TNM staging system does not fully address the variations in glottic squamous cell carcinoma (SCC) extension and subsites involvement, especially if treated with transoral laser microsurgery (TOLMS). This study aims …
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Adjuvant treatment in elderly patients undergoing transoral surgery for HPV-related oropharyngeal cancer.
[OBJECTIVES] Older adults are an increasing proportion of patients with HPV-related oropharyngeal squamous cell carcinoma (OPSCC), and transoral surgery (TOS) remains a valid treatment option for this population. This study aimed to evaluat…
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End-To-Side Venous Anastomosis in Head and Neck Free Flap Reconstruction: A Systematic Review and Meta-Analysis.
[PURPOSE] We performed a systematic review and meta-analysis to evaluate the outcomes of end-to-side (ETS) anastomosis to the internal jugular vein (IJV) in head and neck free flap reconstruction. Postoperative outcomes of ETS were compared…
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Optimising oncologic outcomes in pT3 glottic cancers treated by transoral laser microsurgery: the impact of adjuvant treatment.
[OBJECTIVE] The treatment strategy for cT3 glottic squamous cell carcinoma (SCC) is far from being standardised, and the role of adjuvant treatment(s) is not clearly defined. This study assessed the impact of adjuvant (chemo-)radiotherapy (…
- Comments on: Value and role of surgical margins in transoral laser microsurgery of the larynx, literature review and clinical considerations.
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Enhancing quality of life in head and neck cancer patients: a comparative analysis of 3D exoscope-assisted surgery vs. traditional approaches.
[INTRODUCTION] The increasing population of survivors of head and neck carcinomas is becoming more conspicuous. Consequently, the pivotal role of quality of life, particularly elucidated through the assessment of dysphagia and dysphonia, is…
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The impact of margins in laryngeal cancer patients treated with transoral laser microsurgery: a systematic review and meta-analysis.
[PURPOSE] In laryngeal squamous cell carcinoma (LSCC) treated with transoral laser microsurgery (TOLMS), the status of margins significantly affected local control. When a positive or close margin is present, there is no ubiquitous consensu…
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Comprehensive Evaluation of Vocal Outcomes and Quality of Life after Total Laryngectomy and Voice Restoration with J-Flap and Tracheoesophageal Puncture.
[BACKGROUND] Tracheoesophageal puncture with a voice prosthesis is the gold standard for speech rehabilitation in patients that receive a laryngopharyngectomy. However, a novel surgical technique, using a tubularized anterolateral tight fla…
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Quality of life after transoral CO laser posterior cordotomy with or without partial arytenoidectomy for bilateral adductor vocal cord paralysis.
[OBJECTIVES] Bilateral adductor vocal cord paralysis (BAVCP) is a rare and challenging condition whose main consequence is reduction of airway patency at the glottic level, often causing respiratory distress, while vocal function tends to r…