논문 목록
5건 · 최신순-
DystoniaBoTXNet: Novel Neural Network Biomarker of Botulinum Toxin Efficacy in Isolated Dystonia.
[OBJECTIVE] Isolated dystonia is characterized by abnormal, often painful, postures and repetitive movements due to sustained or intermittent involuntary muscle contractions. Botulinum toxin (BoTX) injections into the affected muscles are t…
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Central voice production and pathophysiology of spasmodic dysphonia.
[OBJECTIVE] Our ability to speak is complex, and the role of the central nervous system in controlling speech production is often overlooked in the field of otolaryngology. In this brief review, we present an integrated overview of speech p…
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Phenomenology, genetics, and CNS network abnormalities in laryngeal dystonia: A 30-year experience.
[OBJECTIVE] Laryngeal dystonia (LD) is a functionally specific disorder of the afferent-efferent motor coordination system producing action-induced muscle contraction with a varied phenomenology. This report of long-term studies aims to rev…
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A novel therapeutic agent, sodium oxybate, improves dystonic symptoms via reduced network-wide activity.
Oral medications for the treatment of dystonia are not established. Currently, symptoms of focal dystonia are managed with botulinum toxin injections into the affected muscles. However, the injection effects are short-lived and not benefici…
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An open-label study of sodium oxybate in Spasmodic dysphonia.
[OBJECTIVES/HYPOTHESIS] Spasmodic dysphonia (SD) is a task-specific laryngeal dystonia that affects speech production. Co-occurring voice tremor (VT) often complicates the diagnosis and clinical management of SD. Treatment of SD and VT is l…