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Outcomes of microvascular head and neck reconstruction in solid organ transplant patients: A single institution experience and meta-analysis.
[BACKGROUND] Solid organ transplant recipients are at increased risk of developing head and neck squamous cell carcinoma (HNSCC). These patients often require free flap reconstruction; however, data on outcomes in this immunosuppressed popu…
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Impact of Preoperative Multidisciplinary Conference on Head and Neck Reconstruction Outcomes.
[INTRODUCTION] Head and neck oncologic resections with microvascular reconstruction are lengthy and complex procedures with inefficiencies in the operating room (OR) associated with increased complications and higher costs. Multidisciplinar…
- Towards improved speech and swallowing outcomes after hemiglossectomy reconstruction: Impact of neurotization and free flap choice.
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Hypothermia During Microsurgical Head and Neck Reconstruction and Incidence of Venous Thromboembolism.
[IMPORTANCE] Venous thromboembolism (VTE) is a severe complication after microsurgical free tissue transfer (FTT) to the head and neck. Hypothermia during surgery is a modifiable risk factor, and avoiding it may reduce the postoperative VTE…
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Use of Tranexamic Acid in Head and Neck Free Flap Reconstruction.
[INTRODUCTION] Tranexamic acid (TXA) is commonly used in surgical settings to reduce blood loss. Due to its antifibrinolytic properties, TXA theoretically increases the risk of thrombosis. In this study, the use of TXA was assessed in patie…
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Computer-Aided Design and Manufacturing in Free Fibula Reconstruction of the Mandible: Comparison of Long-Term Outcomes.
[BACKGROUND] Preoperative computer-aided design and computer-aided manufacturing (CAD/CAM) revolutionized head and neck reconstruction after extirpative surgery. However, studies performing head-to-head comparison to the conventional techni…
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Drain Fluid Amylase as an Early Negative Predictor of Salivary Fistula Following Free Flap Reconstruction.
[OBJECTIVES] Salivary fistula is a known complication following head and neck free flap reconstruction involving the aerodigestive tract. We sought to examine the association between surgical drain fluid amylase and salivary fistula formati…
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Preoperative Care Clinic Improves Survival for Patients Undergoing Free-Flap Reconstruction.
[OBJECTIVE] This study aims to evaluate whether perioperative care improves postoperative outcomes for head and neck reconstruction patients with preexisting health conditions. [STUDY DESIGN] Retrospective cohort study. [SETTING] Single t…
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Co-surgery in head and neck microvascular reconstruction.
[PURPOSE] Co-surgery with two attending reconstructive surgeons is becoming increasingly common in breast microvascular reconstruction due to case complexity and the potential for improved outcomes and operative efficiency. The impact of co…
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Machine Perfusion Deters Ischemia-Related Derangement of a Rodent Free Flap: Development of a Model.
[INTRODUCTION] Machine perfusion can enable isolated support of composite tissues, such as free flaps. The goal of perfusion in this setting is to preserve tissues prior to transplantation or provide transient support at the wound bed. This…
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A Model to Study Wound Healing Over Exposed Avascular Structures in Rodents With a 3D-Printed Wound Frame.
[BACKGROUND] Soft tissue defects with exposed avascular structures require reconstruction with well-vascularized tissues. Extensive research is ongoing to explore tissue engineered products that provide durable coverage. However, there is a…
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The Future of Microsurgery: Vascularized Composite Allotransplantation and Engineering Vascularized Tissue.
[BACKGROUND] Microsurgical techniques have revolutionized the field of reconstructive surgery and are the mainstay for complex soft tissue reconstruction. However, their limitations have promoted the development of viable alternatives. This…
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Association of prealbumin with complications after total laryngectomy with free flap reconstruction.
[OBJECTIVE] Malnutrition is an important risk factor for patient surgical outcomes. This is especially true for head and neck cancer (HNC) patients receiving a total laryngectomy with free flap reconstruction (TLwFFR). Preoperative prealbum…
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Head and Neck Reconstruction in Patients with Polycythemia Vera: Case Series and Literature Review.
Polycythemia vera (PV) is a myeloproliferative disease with overproduction of erythrocytes, leukocytes, and platelets causing an increased risk of both thrombosis and hemorrhage. There are limited reports and no established guidelines for …
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Venous Thromboembolism Rates After Free Flap Reconstruction of the Head and Neck Region.
[BACKGROUND] Venous thromboembolism (VTE) is a major concern for the postoperative hospitalized patient, especially after long and complex procedures. Cancer itself also contributes to the hypercoagulable state, further complicating the man…
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Automated Decellularization of the Rodent Epigastric Free Flap: A Comparison of Sodium Dodecyl Sulfate-Based Protocols.
[BACKGROUND] Free tissue transfer to cover complex wounds with exposed critical structures results in donor-site morbidity. Perfusion decellularization and recellularization of vascularized composite tissues is an active area of research t…
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Association between venous thromboembolism rates and different prophylactic anticoagulation regimens in patients undergoing free flap reconstruction of the head and neck region.
[BACKGROUND] Venous Thromboembolism (VTE) is a serious complication after free tissue transfer to the head and neck (H&N). However, an optimal antithrombotic prophylaxis protocol is not defined in the literature. Enoxaparin 30 mg twice dail…
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Discharge Disposition After Head and Neck Reconstruction: Effect on Adjuvant Therapy and Outcomes.
[OBJECTIVES] Head and neck cancer patients that require major reconstruction often have advanced-stage disease. Discharge disposition of patients can vary and impact time to adjuvant treatment. We sought to examine outcomes in patients disc…
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The Role of Autologous Fat Grafting in Rhinoplasty.
Rhinoplasty is one of the most popular aesthetic surgeries worldwide and often includes grafting techniques to achieve optimal results. One of these grafting techniques is autologous fat transfer, which has been used to increase volume, cam…
- Extracorporeal Perfusion of Vascularized Composite Tissues: The Bridging Role of an Emerging Technology in Reconstructive Microsurgery.
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Standard Fixed Enoxaparin Dosing for Venous Thromboembolism Prophylaxis Leads to Low Peak Anti-Factor Xa Levels in Both Head and Neck and Breast Free Flap Patients.
[BACKGROUND] Venous thromboembolism (VTE) is a serious complication, particularly in cancer patients undergoing free flap reconstruction. Subcutaneous enoxaparin is the conventional prophylaxis for VTE prevention, and serum anti-factor Xa …
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Assessment of BMI and Venous Thromboembolism Rates in Patients on Standard Chemoprophylaxis Regimens After Undergoing Free Tissue Transfer to the Head and Neck.
[IMPORTANCE] Venous thromboembolism (VTE) is a severe complication after free tissue transfer to the head and neck (H&N). Enoxaparin 30 mg twice daily (BID) is a common regimen for chemoprophylaxis. However, differences in enoxaparin metabo…
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Consensus of free flap complications: Using a nomenclature paradigm in microvascular head and neck reconstruction.
[BACKGROUND] We aim to define a set of terms for common free flap complications with evidence-based descriptions. [METHODS] Clinical consensus surveys were conducted among a panel of head and neck/reconstructive surgeons (N = 11). A conten…
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Surgical factors associated with patient-reported quality of life outcomes after free flap reconstruction of the oral cavity.
[OBJECTIVES] To determine which surgical factors are associated with quality-of-life (QOL) outcomes in oral cavity cancer survivors after free flap reconstruction of the oral cavity. [PATIENTS AND METHODS] A cross-sectional study was condu…
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Head and Neck Microsurgeon Practice Patterns and Perceptions Regarding Venous Thromboembolism Prophylaxis.
[BACKGROUND] Patients undergoing head and neck (H&N) microvascular reconstruction comprise a population at high risk for venous thromboembolism (VTE). Free flap and VTE thromboprophylaxis may coincide but tend to vary from surgeon to surge…
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Heterotopic Transplantation of Allogeneic Vertical Rectus Abdominis Myocutaneous Flaps in Miniature Swine.
[BACKGROUND] Vascularized composite tissue allotransplantation (VCA) opens new possibilities for reconstruction of complex tissue defects, including upper extremity and facial transplantation. The main challenges in VCA transplantation are …
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Milestones in Plastic Surgery: Attending Assessment versus Resident Assessment.
[BACKGROUND] The Plastic Surgery Milestones Project was jointly conceived by the Accreditation Council for Graduate Medical Education and the American Board of Plastic Surgery as a tool to improve granularity in resident feedback. Resident …