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Prognostic Value of Baseline Systemic Immune-Inflammation Index in Advanced Intrahepatic Cholangiocarcinoma Treated with First-Line Gemcitabine-Cisplatin Plus PD-L1 Inhibitor: A Single-Center Retrospective Study.
[BACKGROUND] Gemcitabine-cisplatin (GC) combined with a programmed death-ligand 1 (PD-L1) inhibitor has become an important first-line regimen for advanced intrahepatic cholangiocarcinoma (ICC). However, overall efficacy remains modest, and…
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Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine.
Relapsed/refractory (R/R) disease is a major hurdle to long-term survival of acute myeloid leukemia (AML) patients treated with intensive cytarabine (AraC)-based chemotherapy. R/R AML salvage treatment with venetoclax (VEN) + azacitidine (A…
- Megakaryocytic Emperipolesis in Acute Myeloid Leukemia with Trisomy 8.
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Development and validation of a multiparameter prognostic model for extranodal natural killer/T-cell lymphoma: Integration of clinical, pathological, and molecular biomarkers.
[OBJECTIVES] The objectives of the study are to develop and validate a novel prognostic model for extranodal natural killer/T-cell lymphoma (ENKTCL) by integrating clinical and pathological parameters. [MATERIAL AND METHODS] We retrospecti…
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A survival prognostic model for gastro-intestinal diffuse large B-cell lymphomas: A multicenter retrospective study.
Primary gastro-intestinal lymphomas (PGIL) are the most common extra-nodal lymphomas. Currently, existing prognostic models for gastrointestinal diffuse large B-cell lymphoma (GI-DLBCL) like the HLAMA model is lack of rigorous external vali…
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A novel valvuloplastic esophagogastrostomy for laparoscopic proximal gastrectomy: Parachute-tunnel-style technique and animal experiments of relationship between anastomotic stenosis and gastric remnant seromuscular flap blood supply.
[BACKGROUND] Among several esophagogastric anastomosis techniques with additional mechanical antireflux functions after laparoscopic proximal gastrectomy (LPG), the double-flap technique (DFT) has received increased attention recently. Howe…
- A commentary on "Multimodal radiopathomics approach for predictions of prognosis and immunotherapy response in patients with gastric cancer: a multicohort retrospective study".
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Hepatic arterial infusion chemotherapy combined with apatinib plus camrelizumab for advanced hepatocellular carcinoma with type Vp4 portal vein tumor thrombosis: a multicenter propensity score-matching analysis.
[BACKGROUND] Portal vein main trunk invasion is a serious and difficult complication of hepatocellular carcinoma (HCC), with extremely poor prognosis and limited treatment options. The traditional standard sorafenib has a limited efficacy. …
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PRMT5-mediated symmetric dimethylation of SHBs at Arg169 stabilizes SHBs and promotes angiogenesis and tumor growth.
The small hepatitis B surface antigen (SHBs), an oncogenic protein encoded by hepatitis B virus (HBV), contributes to hepatocellular carcinoma. However, the post-translational regulatory mechanisms of SHBs remain incompletely defined. Here,…
- PSMG3 enhances the proliferation and metastasis of hepatocellular carcinoma via inhibiting HDAC6.
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The Single-Cell and Spatial Transcriptomics Atlas of Epithelial-Fibroblast Interactions in Colorectal Cancer.
[BACKGROUND] Colorectal cancer (CRC) exhibits extensive cellular heterogeneity and complex tumor microenvironment (TME) interactions, which influence tumor progression and treatment response. However, the precise interplay between epithelia…
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Smoking promotes colorectal cancer via the CKAP2L/AREG axis.
The link between smoking and colorectal cancer (CRC) is well‑established; however, further research is needed to fully understand the specific effects of tobacco on the development of this type of cancer. The aim of the present study was to…
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Systematic Pathway Screening via Integrated Machine Learning Identifies FOXO-Mediated Transcription Signature for Robust Immunotherapy Response Prediction in Non-Small Cell Lung Cancer.
[BACKGROUND] Non-small cell lung cancer (NSCLC), accounting for 80% of lung cancer cases, remains a leading cause of cancer-related mortality globally. While immune checkpoint inhibitors (ICIs) have improved outcomes, their efficacy is limi…
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The Survival for Pneumonectomy After Neoadjuvant Therapy in Non-small Cell Lung Cancer: A Retrospective Study from the National Cancer Center in China.
[BACKGROUND] This study aimed to evaluate the impact of pneumonectomy after neoadjuvant therapy by assessing postoperative outcomes, survival prognosis, and recurrence patterns. [METHODS] A retrospective analysis of patients with non-small…
- ASO Author Reflections: The Survival for Pneumonectomy After Neoadjuvant Therapy in Non-Small Cell Lung Cancer.
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Norcantharidin inhibits the EZH2-mediated JAK2/STAT3 signaling pathway to inhibit the proliferation of non-small cell lung cancer.
[OBJECTIVE] The purpose of this study was firstly to investigate the anti-tumor effects of NCTD on NSCLC cell proliferation, apoptosis, migration, and invasion. Secondly, it aimed to explore whether these effects were associated with the mo…
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Multi-omics analysis and experiments validate the tumor-suppressive role of mitochondrial lipid metabolism gene ACSM5 in lung adenocarcinoma and its impact on the immune microenvironment.
[BACKGROUND] Lung adenocarcinoma (LUAD) is the most prevalent subtype of non-small cell lung cancer, characterized by high incidence and poor prognosis. Mitochondrial lipid metabolism (MTLM) contributes to tumor proliferation and drug resis…
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Machine learning-driven identification of shared and disease-specific mitochondria-related genes in COPD, NSCLC, and NSCLC with COPD.
Chronic obstructive pulmonary disease (COPD) and non-small-cell lung cancer (NSCLC) often coexist; here, the shared mitochondrial drivers were investigated. Serum from 30 subjects (seven controls, nine COPD, eight NSCLC, and six NSCLC with …
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Toxicological Implications of mA Dysregulation: SH3PXD2A-AS1-Driven PD-L1 Overexpression Promotes Immune Evasion in NSCLC.
The lncRNA SH3PXD2A-AS1 drives therapy resistance in non-small cell lung cancer (NSCLC) through mA-mediated PD-L1 overexpression, representing a novel molecular toxicology paradigm. In the present work, the functional significance of SH3PXD…
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The landscape of responses to neoadjuvant immunotherapy in resectable Kirsten rat sarcoma viral oncogene homolog-mutant lung adenocarcinoma: Clinical heterogeneity and correlative immunologic analysis.
[BACKGROUND] Kirsten rat sarcoma viral oncogene homolog (KRAS)-mutant lung adenocarcinoma (LUAD) typically demonstrates limited response to neoadjuvant immunotherapy (NIT). Elucidating the immune determinants that differentiate responders f…
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Auxiliary Liver Transplantation With Delayed Total Hepatectomy: Evolution From 2-stage APOLT to RAPID Following the ALPPS Principles.
The resection and partial liver segment 2/3 transplantation with delayed total hepatectomy (RAPID) represents an innovative fusion of 2 of the most challenging procedures of modern liver surgery: auxiliary partial orthotopic liver transplan…
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Cardiooncology in the ICU - Cardiac Urgencies in Cancer Care.
Cardiovascular disease is an increasing risk of morbidity and mortality in cancer patients, related to an growing number of aging survivors with pre-existing cardiovascular disease and the use of traditional and novel cancer therapies with …
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Gleason Score 3 + 4 (Grade Group 2) Prostate Cancer on Biopsy and Postoperative Pathological Upgrading: A Systematic Review and Meta-Analysis.
The clinical heterogeneity of needle biopsy (Bx)3 + 4 presents uncertainty to active surveillance as a treatment option for prostate cancer (PCa) patients. This meta-analysis demonstrates that 23.4% of Bx3 + 4 were upgraded at radical prost…
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Total thyroidectomy versus lobectomy for unilateral papillary thyroid cancer and lateral lymph node metastasis: A systematic review and meta-analysis.
[BACKGROUND] The optimal surgical approach for unilateral papillary thyroid cancer with lateral lymph node metastasis remains a subject of ongoing debate. This systematic review and meta-analysis aims to provide available evidence to facili…
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Beyond the Plate: Unveiling the Association Between Meat Consumption and Colorectal Cancer Risk.
[BACKGROUND AND AIM] The consumption of meat, particularly processed and red meat, is believed to increase the risk of colorectal cancer (CRC). This study aims to conduct a meta-analysis to clarify the association between the consumption of…
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Isoimperatorin suppresses triple-negative breast cancer by modulating miR-874-3p/POU2F1 axis: a new avenue for metabolic and redox intervention.
[BACKGROUND] Metabolic alterations are key factors driving the development of breast cancer. Among them, metabolic reprogramming is an important biological hallmark of breast cancer. It is crucial to gain in-depth understanding of the relev…
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Emergent surgical airway for patients with head and neck conditions: a systematic review and meta-analysis.
Acute airway obstruction in patients with head and neck conditions often results in a 'can't intubate, can't oxygenate' (CICO) situation, which requires a different management approach than the airway emergency guidelines in the context of …
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Synchronous PET/MR imaging and visualizing penetration of nanomedicine within tumor based on Ga-NaGdF probes.
Magnetic resonance imaging (MRI) and nuclear medicine imaging are widely used for cancer detection due to their high soft tissue resolution and sensitivity. Each modality has inherent limitations; therefore, integrated techniques such as po…
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Microbial crosstalk along the oral-gut axis: organ-specific oncogenic adaptations of Porphyromonas gingivalis and Fusobacterium nucleatum.
The oral-gut microbiota axis is increasingly recognized as a critical bridge linking local infection to systemic diseases. Growing evidence demonstrates that oral microbes not only enter the gut via saliva, bloodstream, and direct migration…
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Targeting tumor dormancy: the next frontier in gastrointestinal stromal tumor therapy.
Gastrointestinal stromal tumors (GISTs), the most common mesenchymal neoplasms of the digestive tract, are primarily driven by mutations in KIT/PDGFRA. The remarkable success of tyrosine kinase inhibitors such as imatinib (IM) in treating G…