Plasma bupivacaine concentrations during combined regional and general anaesthesia for resection and reconstruction of head and neck carcinomata.
Abstract
Venous plasma bupivacaine concentrations were measured in patients undergoing resection and reconstruction surgery for intra-oral malignancy. Vth cranial nerve and cervical plexus blocks were performed using 0.5% bupivacaine. Total dosage was higher than recommended by U.K. manufacturers. Mean peak venous plasma concentrations were higher than previously recorded. A significant different was found in the peak concentrations when adrenaline was included. The significance of these results in relation to systemic toxicity and recommended dosage is discussed.
추출된 의학 개체 (NER)
| 유형 | 영어 표현 | 한국어 / 풀이 | UMLS CUI | 출처 | 등장 |
|---|---|---|---|---|---|
| 해부 | Plasma bupivacaine
|
scispacy | 1 | ||
| 해부 | cervical plexus
|
scispacy | 1 | ||
| 합병증 | venous plasma
|
scispacy | 1 | ||
| 약물 | adrenaline
|
에피네프린 | dict | 1 | |
| 약물 | bupivacaine
|
C0006400
bupivacaine
|
scispacy | 1 | |
| 질환 | head and neck carcinomata
|
C3887461
Head and Neck Carcinoma
|
scispacy | 1 | |
| 질환 | malignancy
|
C0006826
Malignant Neoplasms
|
scispacy | 1 | |
| 질환 | Vth cranial nerve
|
C0010268
Cranial Nerves
|
scispacy | 1 | |
| 질환 | toxicity
|
C0040539
Toxicity aspects
|
scispacy | 1 | |
| 질환 | intra-oral malignancy
|
scispacy | 1 | ||
| 기타 | patients
|
scispacy | 1 | ||
| 기타 | Vth cranial nerve
|
scispacy | 1 | ||
| 기타 | U.K.
|
scispacy | 1 |
MeSH Terms
Aged; Anesthesia, Conduction; Anesthesia, General; Bupivacaine; Cervical Plexus; Epinephrine; Female; Head and Neck Neoplasms; Humans; Male; Middle Aged; Nerve Block; Surgery, Plastic; Time Factors
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