Autoimmune hair loss (alopecia areata) transferred by T lymphocytes to human scalp explants on SCID mice.
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TL;DR
Data indicate that alopecia areata is mediated by T cells which recognize a follicular autoantigen, and this disease is often psychologically devastating.
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📑 인용한 논문 (6) ▾
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연도별 인용 (2012–2026) · 합계 111
OpenAlex 토픽 ·
Hair Growth and Disorders
Autoimmune Bullous Skin Diseases
Hereditary Neurological Disorders
Abstract 🌐 Abstract
Alopecia areata is a tissue-restricted autoimmune disease of the hair follicle, which results in hair loss and baldness. It is often psychologically devastating. The role of T lymphocytes in this disorder was investigated with cell transfer experiments. Scalp explants from patients were transplanted to severe combined immunodeficiency (SCID) mice and injected with autologous T lymphocytes isolated from involved scalp. T lymphocytes which had been cultured with hair follicle homogenate along with antigen-presenting cells were capable of inducing the changes of alopecia areata, including hair loss and perifollicular infiltrates of T cells, along with HLA-DR and ICAM-1 expression of the follicular epithelium. Similar changes were not noted in grafts injected with scalp-derived T cells that had not been cultured with follicular homogenate. These data indicate that alopecia areata is mediated by T cells which recognize a follicular autoantigen.
Data indicate that alopecia areata is mediated by T cells which recognize a follicular autoantigen, and this disease is often psychologically devastating.
APA 7
Gilhar, A., Ullmann, Y., Berkutzki, T., Assy, B., & Kalish, R. S. (1998). Autoimmune hair loss (alopecia areata) transferred by t lymphocytes to human scalp explants on scid mice.. The Journal of clinical investigation, 101(1), 62-7. https://doi.org/10.1172/JCI551
Vancouver
Gilhar A, Ullmann Y, Berkutzki T, Assy B, Kalish RS. Autoimmune hair loss (alopecia areata) transferred by T lymphocytes to human scalp explants on SCID mice. Jour. clin. inve.. 1998;101(1):62-7. doi:10.1172/JCI551
AMA 11
Gilhar A, Ullmann Y, Berkutzki T, Assy B, Kalish RS. Autoimmune hair loss (alopecia areata) transferred by T lymphocytes to human scalp explants on SCID mice. Jour. clin. inve.. 1998;101(1):62-7. doi:10.1172/JCI551
Chicago
Gilhar, A., Ullmann, Y., Berkutzki, T., Assy, B., and Kalish, R. S.. 1998. "Autoimmune hair loss (alopecia areata) transferred by T lymphocytes to human scalp explants on SCID mice." The Journal of clinical investigation 101 (1): 62-7. https://doi.org/10.1172/JCI551
MLA 9
Gilhar, A., et al. "Autoimmune hair loss (alopecia areata) transferred by T lymphocytes to human scalp explants on SCID mice." The Journal of clinical investigation, vol. 101, no. 1, 1998, pp. 62-7. doi:10.1172/JCI551.
PMID
9421466 ↗
DOI
10.1172/JCI551
🏷️ 키워드 / MeSH 📖 같은 키워드 OA만
인용 관계
그래프 OA 노드: 7/8 (88%)
· 참조 0편 · 후속 7편
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