Effect of minoxidil on proliferation and apoptosis in dermal papilla cells of human hair follicle.
4/5 보강
TL;DR
It is suggested that minoxidil stimulates the growth of human hairs by prolonging anagen through these proliferative and anti-apoptotic effects on DPCs.
📑 코퍼스 인용 관계
· 인용됨 73
📑 인용한 논문 (6) ▾
- Expanding the therapeutic landscape of minoxidil for androgenetic alopecia: topical, oral … Frontiers in pharmacology · 2025
- Efficacy and safety of oral minoxidil in the treatment of alopecia: a single-arm rate meta… Frontiers in pharmacology · 2025
- Updates in Treatment for Androgenetic Alopecia. Annals of dermatology · 2025
- Synergistic effects of Rhynchosia nulubilis and Polygonum multiflorum extract combination … PloS one · 2025
- Analysis of Berberine as a Potential Therapeutic Approach for Various Signalling Pathways… Recent advances in inflammation & allergy drug discovery · 2025
- Topical dutasteride for androgenic alopecia: current state and prospects. Therapeutic delivery · 2025
연도별 인용 (2012–2026) · 합계 180
OpenAlex 토픽 ·
Hair Growth and Disorders
Dyeing and Modifying Textile Fibers
Skin and Cellular Biology Research
Abstract 🌐 Abstract
[BACKGROUND] Minoxidil has been widely used to treat androgenetic alopecia, but little is known about its pharmacological activity or about the identity of its target cells in hair follicles. We hypothesized that minoxidil has direct effects on the proliferation and apoptosis of dermal papilla cells (DPCs) of human hair follicle.
[OBJECTIVE] To elucidate the mechanism of topical minoxidil action in terms of stimulating hair growth.
[METHODS] We evaluated cell proliferations in cultured DPCs by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) and measured the expressions of extracellular signal-regulated kinase (ERK), Akt, Bcl-2, and Bax by Western blot. We also measured elongation of hair follicles in organ culture.
[RESULTS] Minoxidil significantly increased the proliferation of DPCs. The levels of ERK phosphorylation and of phosphorylated Akt increased significantly 1 h post-treatment; percentage increase of ERK phosphorylation was 287% at 0.1 microM and 351% at 1.0 microM of minoxidil, and that of Akt phosphorylation was 168% at 0.1 microM and 257% at 1.0 microM of minoxidil. 1.0 microM of minoxidil increased Bcl-2 expression over 150%, while 1.0 microM of minoxidil decreased Bax expression by more than 50%. Moreover, a significant elongation of individual hair follicles in organ culture was observed after adding minoxidil.
[CONCLUSION] Minoxidil promotes the survival of human DPCs by activating both ERK and Akt and by preventing cell death by increasing the ratio of Bcl-2/Bax. We suggest that minoxidil stimulates the growth of human hairs by prolonging anagen through these proliferative and anti-apoptotic effects on DPCs.
[OBJECTIVE] To elucidate the mechanism of topical minoxidil action in terms of stimulating hair growth.
[METHODS] We evaluated cell proliferations in cultured DPCs by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) and measured the expressions of extracellular signal-regulated kinase (ERK), Akt, Bcl-2, and Bax by Western blot. We also measured elongation of hair follicles in organ culture.
[RESULTS] Minoxidil significantly increased the proliferation of DPCs. The levels of ERK phosphorylation and of phosphorylated Akt increased significantly 1 h post-treatment; percentage increase of ERK phosphorylation was 287% at 0.1 microM and 351% at 1.0 microM of minoxidil, and that of Akt phosphorylation was 168% at 0.1 microM and 257% at 1.0 microM of minoxidil. 1.0 microM of minoxidil increased Bcl-2 expression over 150%, while 1.0 microM of minoxidil decreased Bax expression by more than 50%. Moreover, a significant elongation of individual hair follicles in organ culture was observed after adding minoxidil.
[CONCLUSION] Minoxidil promotes the survival of human DPCs by activating both ERK and Akt and by preventing cell death by increasing the ratio of Bcl-2/Bax. We suggest that minoxidil stimulates the growth of human hairs by prolonging anagen through these proliferative and anti-apoptotic effects on DPCs.
It is suggested that minoxidil stimulates the growth of human hairs by prolonging anagen through these proliferative and anti-apoptotic effects on DPCs.
APA 7
Han, J. H., Kwon, O. S., Chung, J. H., Cho, K. H., Eun, H. C., & Kim, K. H. (2004). Effect of minoxidil on proliferation and apoptosis in dermal papilla cells of human hair follicle.. Journal of dermatological science, 34(2), 91-8. https://doi.org/10.1016/j.jdermsci.2004.01.002
Vancouver
Han JH, Kwon OS, Chung JH, Cho KH, Eun HC, Kim KH. Effect of minoxidil on proliferation and apoptosis in dermal papilla cells of human hair follicle. Jour. derm. scie.. 2004;34(2):91-8. doi:10.1016/j.jdermsci.2004.01.002
AMA 11
Han JH, Kwon OS, Chung JH, Cho KH, Eun HC, Kim KH. Effect of minoxidil on proliferation and apoptosis in dermal papilla cells of human hair follicle. Jour. derm. scie.. 2004;34(2):91-8. doi:10.1016/j.jdermsci.2004.01.002
Chicago
Han, J. H., Kwon, O. S., Chung, J. H., Cho, K. H., Eun, H. C., and Kim, K. H.. 2004. "Effect of minoxidil on proliferation and apoptosis in dermal papilla cells of human hair follicle." Journal of dermatological science 34 (2): 91-8. https://doi.org/10.1016/j.jdermsci.2004.01.002
MLA 9
Han, J. H., et al. "Effect of minoxidil on proliferation and apoptosis in dermal papilla cells of human hair follicle." Journal of dermatological science, vol. 34, no. 2, 2004, pp. 91-8. doi:10.1016/j.jdermsci.2004.01.002.
PMID
15033191 ↗
🏷️ 키워드 / MeSH 📖 같은 키워드 OA만
- Adult
- Alopecia
- Apoptosis
- Cell Culture Techniques
- Cell Division
- Gene Expression Regulation
- Growth Substances
- Hair Follicle
- Humans
- Minoxidil
- Mitogen-Activated Protein Kinases
- Phosphorylation
- Protein Serine-Threonine Kinases
- Proto-Oncogene Proteins
- Proto-Oncogene Proteins c-akt
- Proto-Oncogene Proteins c-bcl-2
- bcl-2-Associated X Protein
인용 관계
그래프 OA 노드: 8/8 (100%)
· 참조 0편 · 후속 8편
이 논문을 인용한 후속 연구 20
- The Effect of Platelet-Rich Plasma in Hair Regrowth: A Randomized Placebo-Controlled Trial.
- Study of platelet-rich plasma injections in the treatment of androgenetic alopecia through an one-ye…
- Extracellular vesicles derived from MSCs activates dermal papilla cell in vitro and promotes hair fo…
- The effect of autologous activated platelet rich plasma (AA-PRP) injection on pattern hair loss: cli…
- Valproic acid induces hair regeneration in murine model and activates alkaline phosphatase activity …
- Systematic Review of Platelet-Rich Plasma Use in Androgenetic Alopecia Compared with Minoxidil, Fina…
- Minoxidil Promotes Hair Growth through Stimulation of Growth Factor Release from Adipose-Derived Ste…
- Hair-Growth Potential of Ginseng and Its Major Metabolites: A Review on Its Molecular Mechanisms.
- KY19382, a novel activator of Wnt/β-catenin signalling, promotes hair regrowth and hair follicle neo…
- Autologous Micrografts from Scalp Tissue: Trichoscopic and Long-Term Clinical Evaluation in Male and…
- Minoxidil Induction of VEGF Is Mediated by Inhibition of HIF-Prolyl Hydroxylase.
- Red ginseng extract promotes the hair growth in cultured human hair follicles.
- Culture and Differentiation of Human Hair Follicle Dermal Papilla Cells in a Soft 3D Self-Assembling…
- Hair growth potential of extract and its associated mechanisms.
- Lactoferrin promotes hair growth in mice and increases dermal papilla cell proliferation through Erk…
- In vitro hair follicle growth model for drug testing.
- Injections of platelet-rich plasma prepared by automatic blood cell separator combined with topical …
- Efficacy of Platelet-Rich Plasma and Concentrated Growth Factor in Treating Androgenetic Alopecia - …
- Squarticles as a lipid nanocarrier for delivering diphencyprone and minoxidil to hair follicles and …
- New Target for Minoxidil in the Treatment of Androgenetic Alopecia.
같은 제1저자의 인용 많은 논문 (5)
- Feasibility, Safety, and Functional Outcomes of Pelvic Hypothermia Induced Using a Rectal Cooling Device During Robot-Assisted Radical Prostatectomy: A Phase I/II Trial.
- Teriflunomide modulates the PD-1/PD-L1 axis and enhances antitumor immunity in colorectal cancer.
- AcrVA3 Is a Double Strand DNA-Cleaving Anti-CRISPR That Indirectly Inhibits Cas12.
- Functional outcomes of hypothermic robot assisted radical prostatectomy using BELLOCOOL in a randomized controlled trial.
- Intra-articular Stromal Vascular Fraction and Mesenchymal Stem Cell Injections Show Variable Efficacy and Higher Potential Complications Compared to Corticosteroid and Hyaluronic Acid in Treatment of Knee Osteoarthritis: A Meta-analysis of Randomized Controlled Trials.