Androgenetic alopecia: pathogenesis and potential for therapy.
5/5 보강
TL;DR
Discovery of the involvement of the AR gene, and the identification of other genes contributing to the condition, might lead to the development of new and more effective therapies that target the condition at a more fundamental level.
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연도별 인용 (2012–2026) · 합계 236
OpenAlex 토픽 ·
Hair Growth and Disorders
Genetic Neurodegenerative Diseases
Endoplasmic Reticulum Stress and Disease
🇰🇷 한글 요약 🌐 Abstract
【연구 목적】
남성형 탈모(androgenetic alopecia, AGA)의 병태생리를 정리하고, 안드로겐 수용체(androgen receptor, AR) 유전자를 비롯한 분자생물학적 기전 규명이 향후 치료법 개발에 어떻게 기여할 수 있는지 고찰하기 위한 종설이다.
【방법】
AGA의 유병률, 모낭 주기(성장기 anagen, 휴지기 telogen) 변화, 모낭 축소화(miniaturisation), 유전적 소인 및 안드로겐 의존성 기전에 대한 기존 문헌을 종합 검토하였다. 또한 과학적으로 입증된 치료제(피나스테리드 finasteride, 미녹시딜 minoxidil)의 근거를 정리하였다.
【주요 결과】
백인 남성의 50세까지 최대 50%가 영향을 받을 정도로 흔하며, 유전적 소인과 충분한 순환 안드로겐이 결합되어 발생한다. 미리 프로그램된 두피 모낭이 "긴 성장기·짧은 휴지기"에서 "짧은 성장기·긴 휴지기"로 전환되며 점진적 모낭 축소화가 동반되고, 현재까지 AR 유전자만이 관련 유전자로 확인되었다. 과학적으로 효과가 입증된 치료는 피나스테리드와 미녹시딜뿐이나 효과는 환자별 편차가 크다.
【임상적 시사점 (성형외과 의사 관점)】
모발이식(hair transplantation) 상담 시 AGA가 유전·안드로겐 의존성 진행성 질환임을 설명하고, 수술 단독보다는 피나스테리드·미녹시딜 병용을 통한 잔존 모낭 유지 전략을 권고해야 한다. 또한 직접적 건강 위해는 없으나 심리적 고통이 큰 질환이므로 환자 기대치 관리와 치료 반응의 개인차에 대한 사전 고지가 중요하며, 향후 AR 유전자 표적 치료 등 근본적 치료법 등장 가능성을 염두에 둔 장기적 관리 계획 수립이 필요하다.
Androgenetic alopecia occurs in men and women, and is characterised by the loss of hair from the scalp in a defined pattern. Determining factors appear to be genetic predisposition coupled with the presence of sufficient circulating androgens. The prevalence of this condition is high (up to 50% of white males are affected by 50 years of age) and, although there are no serious direct health consequences, the loss of scalp hair can be distressing. Knowledge of the pathogenesis of androgenetic alopecia has increased markedly in recent years. Pre-programmed follicles on the scalp undergo a transformation from long growth (anagen) and short rest (telogen) cycles, to long rest and short growth cycles. This process is coupled with progressive miniaturisation of the follicle. These changes are androgen dependent, and require the inheritance of several genes. To date, only one of these genes, which encodes the androgen receptor (AR), has been identified. Of the many treatments available for androgenetic alopecia, only two (finasteride and minoxidil) have been scientifically shown to be useful in the treatment of hair loss. However, these therapies are variable in their effectiveness. Discovery of the involvement of the AR gene, and the identification of other genes contributing to the condition, might lead to the development of new and more effective therapies that target the condition at a more fundamental level.
【연구 목적】 남성형 탈모(androgenetic alopecia, AGA)의 병태생리를 정리하고, 안드로겐 수용체(androgen receptor, AR) 유전자를 비롯한 분자생물학적 기전 규명이 향후 치료법 개발에 어떻게 기여할 수 있는지 고찰하기 위한 종설이다.
APA 7
Ellis, J. A., Sinclair, R., & Harrap, S. B. (2002). Androgenetic alopecia: Pathogenesis and potential for therapy.. Expert reviews in molecular medicine, 4(22), 1-11. https://doi.org/10.1017/S1462399402005112
Vancouver
Ellis JA, Sinclair R, Harrap SB. Androgenetic alopecia: pathogenesis and potential for therapy. Expe. revi. mole. medi.. 2002;4(22):1-11. doi:10.1017/S1462399402005112
AMA 11
Ellis JA, Sinclair R, Harrap SB. Androgenetic alopecia: pathogenesis and potential for therapy. Expe. revi. mole. medi.. 2002;4(22):1-11. doi:10.1017/S1462399402005112
Chicago
Ellis, J. A., Sinclair, R., and Harrap, S. B.. 2002. "Androgenetic alopecia: pathogenesis and potential for therapy." Expert reviews in molecular medicine 4 (22): 1-11. https://doi.org/10.1017/S1462399402005112
MLA 9
Ellis, J. A., et al. "Androgenetic alopecia: pathogenesis and potential for therapy." Expert reviews in molecular medicine, vol. 4, no. 22, 2002, pp. 1-11. doi:10.1017/S1462399402005112.
PMID
14585162 ↗
🏷️ 키워드 / MeSH 📖 같은 키워드 OA만
인용 관계
그래프 OA 노드: 8/8 (100%)
· 참조 0편 · 후속 8편
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