Finasteride: a review of its use in male pattern hair loss.

Karen J. McClellan; Anthony Markham

doi:10.2165/00003495-199957010-00014

← 뒤로

Finasteride: a review of its use in male pattern hair loss.

🦱 탈모

4/5 보강

Drugs 📖 저널 OA 27.3% 2021~2026 1999 Vol.57(1) p. 111-26 피인용 23회 cited 164 RCR 3.65 Hair Growth and Disorders

TL;DR Oral finasteride promotes scalp hair growth and prevents further hair loss in a significant proportion of men with male pattern hair loss, and is a new approach to the management of this condition, for which treatment options are few.

PICO 자동 추출 (휴리스틱, conf 2/4)

유사 논문

P · Population 대상 환자/모집단

환자: male pattern hair loss

I · Intervention 중재 / 시술

추출되지 않음

C · Comparison 대조 / 비교

추출되지 않음

O · Outcome 결과 / 결론

With its generally good tolerability profile, finasteride is a new approach to the management of this condition, for which treatment options are few. Its role relative to topical minoxidil has yet to be determined.

📑 코퍼스 인용 관계 · 인용됨 23

📑 인용한 논문 (6) ▾

Oral Minoxidil for Alopecia Treatment: Risks, Benefits, and Recommendations. American journal of clinical dermatology · 2026
Hydrodistillate and Its Major Component Damulin B Promote Hair Growth-Inducing Properties… Nutrients · 2024
Piperonylic Acid Promotes Hair Growth by Activation of EGFR and Wnt/β-Catenin Pathway. International journal of molecular sciences · 2024
A Phase I, Open-Label, Sequential, Single-Dose Clinical Trial to Evaluate the Pharmacokine… Advances in therapy · 2024
Combination and Rotational Therapy in Androgenetic Alopecia. Journal of cutaneous and aesthetic surgery · 2023
Hair Growth Effect of DN106212 in C57BL/6 Mouse and Its Network Pharmacological Mechanism … Current issues in molecular biology · 2023

연도별 인용 (2012–2026) · 합계 103

OpenAlex 토픽 · Hair Growth and Disorders Urological Disorders and Treatments Sexual Differentiation and Disorders

McClellan KJ, Markham A

PubMed ↗ DOI ↗ BibTeX ↓ RIS ↓

Abstract

[UNLABELLED] The 5alpha-reductase inhibitor finasteride blocks the conversion of testosterone to dihydrotestosterone (DHT), the androgen responsible for male pattern hair loss (androgenetic alopecia) in genetically predisposed men. Results of phase III clinical studies in 1879 men have shown that oral finasteride 1 mg/day promotes hair growth and prevents further hair loss in a significant proportion of men with male pattern hair loss. Evidence suggests that the improvement in hair count reported after 1 year is maintained during 2 years' treatment. In men with vertex hair loss, global photographs showed improvement in hair growth in 48% of finasteride recipients at 1 year and in 66% at 2 years compared with 7% of placebo recipients at each time point. Furthermore, hair counts in these men showed that 83% of finasteride versus 28% of placebo recipients had no further hair loss compared with baseline after 2 years. The clinical efficacy of oral finasteride has not yet been compared with that of topical minoxidil, the only other drug used clinically in patients with male pattern hair loss. Therapeutic dosages of finasteride are generally well tolerated. In phase III studies, 7.7% of patients receiving finasteride 1 mg/day compared with 7.0% of those receiving placebo reported treatment-related adverse events. The overall incidence of sexual function disorders, comprising decreased libido, ejaculation disorder and erectile dysfunction, was significantly greater in finasteride than placebo recipients (3.8 vs 2.1%). All sexual adverse events were reversed on discontinuation of therapy and many resolved in patients who continued therapy. No other drug-related events were reported with an incidence > or =1% in patients receiving finasteride. Most events were of mild to moderate severity. Oral finasteride is contraindicated in pregnant women because of the risk of hypospadias in male fetuses.

[CONCLUSIONS] Oral finasteride promotes scalp hair growth and prevents further hair loss in a significant proportion of men with male pattern hair loss. With its generally good tolerability profile, finasteride is a new approach to the management of this condition, for which treatment options are few. Its role relative to topical minoxidil has yet to be determined.

📝 환자 설명용 한 줄

Oral finasteride promotes scalp hair growth and prevents further hair loss in a significant proportion of men with male pattern hair loss, and is a new approach to the management of this condition, fo

이 논문을 인용하기

↓ .bib ↓ .ris

APA 7 McClellan, K. J., & Markham, A. (1999). Finasteride: A review of its use in male pattern hair loss.. Drugs, 57(1), 111-26. https://doi.org/10.2165/00003495-199957010-00014

Vancouver McClellan KJ, Markham A. Finasteride: a review of its use in male pattern hair loss. Drugs. 1999;57(1):111-26. doi:10.2165/00003495-199957010-00014

AMA 11 McClellan KJ, Markham A. Finasteride: a review of its use in male pattern hair loss. Drugs. 1999;57(1):111-26. doi:10.2165/00003495-199957010-00014

Chicago McClellan, K. J., and Markham, A.. 1999. "Finasteride: a review of its use in male pattern hair loss." Drugs 57 (1): 111-26. https://doi.org/10.2165/00003495-199957010-00014

MLA 9 McClellan, K. J., and Markham A. "Finasteride: a review of its use in male pattern hair loss." Drugs, vol. 57, no. 1, 1999, pp. 111-26. doi:10.2165/00003495-199957010-00014.

PMID 9951956 ↗

DOI 10.2165/00003495-199957010-00014