Estrogen and progesterone receptors can be maintained in normal human breast epithelial cells in primary culture and after transplantation into nude mice.
Abstract
The estrogen and progesterone receptor expression was determined in breast epithelial cells from reduction mammoplasty specimens. Only a subset of the luminal epithelial cell population was found to be positive for these receptors. When these cells were subsequently cultured in 3-dimensional collagen gel system (in vitro model) or transplanted into nude mice (in vivo model), the cells retained their ability to express both receptors in these experimental systems. The maintenance of primary normal human breast epithelial cells expressing the estrogen and progesterone receptors in experimental systems has not been reported previously.
추출된 의학 개체 (NER)
| 유형 | 영어 표현 | 한국어 / 풀이 | UMLS CUI | 출처 | 등장 |
|---|---|---|---|---|---|
| 해부 | breast
|
유방 | dict | 3 | |
| 시술 | reduction mammoplasty
|
유방성형술 | dict | 1 | |
| 해부 | breast epithelial cells
|
scispacy | 1 | ||
| 해부 | luminal epithelial cell
|
scispacy | 1 | ||
| 해부 | cells
|
scispacy | 1 | ||
| 약물 | progesterone
|
C0033308
progesterone
|
scispacy | 1 | |
| 약물 | estrogen
|
C0014939
estrogens
|
scispacy | 1 | |
| 약물 | luminal
|
C0524462
Luminal region
|
scispacy | 1 | |
| 기타 | Estrogen
|
scispacy | 1 | ||
| 기타 | human breast epithelial cells
|
scispacy | 1 | ||
| 기타 | nude mice
|
scispacy | 1 | ||
| 기타 | collagen
|
scispacy | 1 |
MeSH Terms
Animals; Breast; Cells, Cultured; Epithelial Cells; Female; Humans; Mice; Mice, Nude; Receptors, Estrogen; Receptors, Progesterone; Transplantation, Heterologous
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