Commentary on: Osteogenesis Modulation: Induction of Mandibular Bone Growth in Adults by Electrical Field for Aesthetic Purposes.

We read with great interest the article by Zendejas et al., introducing a novel application of bioelectrical stimulation to induce mandibular bone growth in adults for aesthetic purposes. Their use of negative electrical polarity to achieve long-term skeletal enhancement without implants or osteotomies represents a promising direction in minimally invasive facial skeletal augmentation. However, several scientific and clinical aspects remain insufficiently addressed. The absence of spatial control in the induced osteogenesis raises concerns about asymmetry or ectopic growth, especially in areas where precision is crucial for aesthetic outcomes. Furthermore, the clinical evidence is limited by small sample size (n = 4), lack of randomization, and missing patient-specific variables. The accompanying animal model also lacks histological, mechanical, and mineral assessments to confirm bone quality. Nevertheless, this study sets the stage for future exploration of directed bioelectrical osteogenesis in craniofacial plastic surgery.Level of Evidence IV This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266 .