Efficacy of Platelet-Rich Plasma as an Adjunct to Hair Transplantation: A Systematic Review.

Hair transplantation is a well-established treatment for androgenetic alopecia (AGA), yet the long-term success of grafts can vary due to multiple influencing factors. Platelet-rich plasma (PRP) has gained attention as a potential adjunctive therapy aimed at enhancing graft survival and promoting hair regrowth. This systematic review evaluated the clinical efficacy of PRP when used alongside hair transplantation. A comprehensive search of Scopus, MEDLINE (via PubMed), and DOAJ was conducted from database inception to June 2025. Eligible studies were prospective clinical trials with control groups that investigated the use of PRP in patients undergoing hair transplantation. Three studies, including two randomized controlled trials and one non-randomized controlled study, met the inclusion criteria, encompassing a total of 217 participants. Across all studies, the addition of PRP was associated with improved outcomes, including increased hair density, enhanced follicle survival, and earlier initiation of hair growth. However, notable heterogeneity was observed in PRP preparation methods, treatment protocols, and outcome measures. Furthermore, none of the studies employed standardized evaluation tools or trichoscopic analysis, limiting the consistency and comparability of findings. While the current evidence suggests that PRP may offer clinical benefits as an adjunct to hair transplantation, further high-quality randomized trials with standardized protocols and long-term follow-up are needed to establish its therapeutic role with greater confidence.