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Botulinum Toxin Effects and Its Association with Vitamin and Mineral Supplementation: A Narrative Review.

Nutrients 2026 Vol.18(3)

Puizina E, Martinovic D, Lasic S, Martinovic L, Puizina J, Dediol E, Lupi-Ferandin S, Bozic J

PMC 전문 ↗ 원문 ↗ DOI ↗

관련 도메인

보툴리눔독소 주사 Botulinum Toxin Injection

Abstract

With the emerging global popularity of botulinum neurotoxin (BoNT), both for aesthetical and medical purposes, there is a rising need for achieving better outcomes. The aim of this narrative review was to comprehensively cover the effect of BoNT, as well as its possible interactions with everyday mineral and vitamin supplementation. It is well established that BoNT exerts its paralytic effects through zinc-dependent cleavage of SNARE proteins, blocking acetylcholine release at the neuromuscular junctions. However, after meticulous research of the available literature regarding the effect of oral supplementation on BoNT, there is very scarce data. The effect of zinc supplementation on the duration and effectiveness of BoNT in some facial applications was studied in a couple of clinical studies; however, systematic reviews indicate inconsistent results. Copper acts as a noncompetitive inhibitor, potentially antagonizing BoNT in animal models. Magnesium and calcium exhibit theoretical synergistic or compensatory roles via neuromuscular transmission modulation but lack clinical validation. Vitamin B complex shows no interference in rat studies and vitamin D influences baseline muscle strength and dosing needs, while vitamin E increases bruising risk but not efficacy. Even though zinc supplementation holds promise for potentiating BoNT effects, evidence for both zinc and other supplements remains speculative or contradictory, underscoring the need for randomized controlled trials to develop evidence-based guidelines. Clinicians should assess patient supplementation status pre-treatment to optimize outcomes and minimize complications, particularly advising against high-dose vitamin E peri-procedurally.

추출된 의학 개체 (NER)

유형영어 표현한국어 / 풀이UMLS CUI출처등장
시술 botulinum toxin 보툴리눔독소 주사 dict 1
해부 Mineral scispacy 1
해부 neuromuscular junctions scispacy 1
해부 oral scispacy 1
해부 neuromuscular scispacy 1
해부 muscle scispacy 1
약물 Vitamin and Mineral scispacy 1
약물 vitamin supplementation C0302837
Vitamin supplementation
 scispacy 1
약물 acetylcholine C0001041
acetylcholine
 scispacy 1
약물 BoNT → botulinum neurotoxin C0006055
Botulinum Toxins
 scispacy 1
약물 Magnesium C0024467
magnesium
 scispacy 1
약물 calcium C0006675
calcium
 scispacy 1
약물 Vitamin B C0042849
vitamin B complex
 scispacy 1
약물 vitamin D C0014695
ergocalciferol
 scispacy 1
약물 vitamin E C0042874
vitamin E
 scispacy 1
약물 zinc C0043481
zinc
 scispacy 1
약물 high-dose vitamin E C4744839
Pharmacological Ascorbate
 scispacy 1
약물 Vitamin scispacy 1
약물 Copper scispacy 1
약물 vitamin E peri-procedurally scispacy 1
질환 bruising C0009938
Contusions
 scispacy 1
기타 botulinum neurotoxin scispacy 1
기타 BoNT → botulinum neurotoxin scispacy 1
기타 SNARE scispacy 1
기타 rat scispacy 1
기타 patient scispacy 1

MeSH Terms

Humans; Dietary Supplements; Vitamins; Animals; Botulinum Toxins; Minerals; Zinc

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이 논문이 참조한 문헌 50

외부 PMID 30건 (DB 미수집)

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