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The Effectiveness of Botulinum Toxin Injection for Cricopharyngeal Dysfunction-Related Dysphagia in Nasopharyngeal Carcinoma Patients.

Dysphagia 2026 Vol.41(1) p. 179-189

Hu KH, Lee IP, Tsai SW, Hung DS, Hsieh MH, Chen YJ, Hsiao JR, Huang CC, Ou CY, Chang CC, Lee WT, Tsai ST, Su HC

원문 ↗ DOI ↗

관련 도메인

보툴리눔독소 주사 Botulinum Toxin Injection 내시경 Endoscopic

Abstract

To evaluate the effectiveness of botulinum toxin injection in improving swallowing function in patients with cricopharyngeal muscle dysfunction (CPMD) following radiotherapy for nasopharyngeal carcinoma (NPC). Cohort study. Outpatients with NPC-related CPMD receiving endoscopy-guided botulinum toxin injection at National Cheng Kung University Hospital between 2017-2024. 15 NPC patients with CPMD were enrolled. Swallowing function was assessed using the functional oral intake scale (FOIS), penetration-aspiration scale (PAS), bolus residue scale (BRS), dynamic imaging grade of swallowing toxicity (DIGEST), normalized residue ratio scale for vallecular (NRRS_V) and pyriform sinus (NRRS_P), laryngeal elevation, epiglottic retroflexion, pharyngeal contraction ratio(PCR), bolus clearance ratio (BCR), and temporal swallowing parameters (oral transit time [OTT], pharyngeal response time [PRT], pharyngeal delay time [PDT], pharyngeal transit time [PTT], laryngeal elevation delay time [LEDT]). The Wilcoxon signed-rank test was used to compare pre- and post-injection data. FOIS significantly improved after botulinum toxin injection (p = 0.0002). Objective measures showed a significant reduction in NRRS_P (p = 0.0067). Temporal characteristics also demonstrated significant improvement in OTT, PRT, and PTT (p = 0.0156, p = 0.0303, p = 0.0284, respectively). However, other objective measures showed no significant changes. Botulinum toxin injection may benefit specific swallowing parameters, such as NRRS_P, OTT, PTT, and PRT, and enhance FOIS in NPC patients with radiation-induced CPMD. However, its overall impact on swallowing function remains uncertain.

추출된 의학 개체 (NER)

유형영어 표현한국어 / 풀이UMLS CUI출처등장
시술 botulinum toxin 보툴리눔독소 주사 dict 5
해부 muscle scispacy 1
해부 oral scispacy 1
해부 laryngeal scispacy 1
해부 pharyngeal scispacy 1
해부 PRT scispacy 1
합병증 pyriform sinus scispacy 1
합병증 epiglottic retroflexion scispacy 1
합병증 pharyngeal scispacy 1
약물 PAS → penetration-aspiration scale scispacy 1
약물 [PRT] scispacy 1
약물 OTT scispacy 1
기법 endoscopy 내시경 dict 1
질환 Dysfunction-Related Dysphagia scispacy 1
질환 Nasopharyngeal Carcinoma C2931822
Nasopharyngeal carcinoma
 scispacy 1
질환 muscle dysfunction scispacy 1
질환 CPMD → cricopharyngeal muscle dysfunction scispacy 1
질환 NPC → nasopharyngeal carcinoma C2931822
Nasopharyngeal carcinoma
 scispacy 1
질환 toxicity C0040539
Toxicity aspects
 scispacy 1
질환 epiglottic retroflexion scispacy 1
질환 Nasopharyngeal Carcinoma Patients scispacy 1
질환 NPC patients scispacy 1
질환 BRS → bolus residue scale scispacy 1
질환 PRT scispacy 1
기타 patients scispacy 1
기타 NPC-related scispacy 1
기타 vallecular scispacy 1
기타 BCR → bolus clearance ratio scispacy 1
기타 PTT scispacy 1
기타 FOIS → functional oral intake scale scispacy 1

MeSH Terms

Humans; Deglutition Disorders; Male; Female; Middle Aged; Nasopharyngeal Carcinoma; Pharyngeal Muscles; Nasopharyngeal Neoplasms; Aged; Treatment Outcome; Adult; Deglutition; Botulinum Toxins; Cohort Studies; Neuromuscular Agents

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외부 PMID 30건 (DB 미수집)

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