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26건 · 최신순-
Iatrogenic botulism: a risk for botulinum toxin's medical use?
Botulinum toxin (BT) is infamous for its extreme toxicity. If it enters the bloodstream, it can cause botulism presenting with a typical pattern of motor and autonomic dysfunction. An international expert panel organised by IAB-Interdiscipl…
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The Evolution of Female Authorship in Facial Plastic Surgery: Changing Trends Over Time.
[BACKGROUND] Women have historically been underrepresented in surgical subspecialties like facial plastic surgery. Authorship is a key metric in career progression; hence, it is important to assay progress in this domain. [STUDY OBJECTIVES…
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Characterizing Hearing Outcomes Following Treatment of Cerebellopontine Angle Meningiomas.
[OBJECTIVES] To characterize treatment and hearing outcomes for cerebellopontine angle (CPA) meningiomas with inherent risks of hearing loss and identify predictors of hearing loss for surgically treated lesions. [DESIGN] Retrospective cha…
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Validation of the Asian Midface Volume Deficit Severity Scale.
[BACKGROUND] Anatomical differences in facial aging and aesthetic needs of Asian and Caucasian individuals have led to disparate clinical rejuvenation strategies using filler augmentation for midface volume deficits. Therefore, the Asian Mi…
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Botulinum Toxin Type A Injection Near the Stylomastoid Foramen: A Safe and Effective Therapeutic Modality for Tinnitus in Patients With Hemifacial Spasm.
[OBJECTIVE] This study aimed to assess the efficacy and safety of botulinum toxin type A (BTX-A) injection near the stylomastoid foramen for tinnitus in patients with hemifacial spasm (HFS). [STUDY DESIGN] Retrospective study from 2011 to …
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Effective botulinum toxin treatment in different patterns of cervical dystonia: a retrospective SPECT and EMG study.
[BACKGROUND] The Col-Cap classification for cervical dystonia (CD) is proposed to optimize treatment strategy with botulinum toxin type A (BTX-A). Although this concept has been used for 15 years, the efficacy of BTX-A in various CD pattern…
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Optimal botulinum toxin therapy of dystonia in Germany: what would it cost?
Botulinum toxin (BT) therapy is the therapy of choice for most forms of dystonia. We want to describe its costs, if all dystonia patients in Germany would have access to optimal BT therapy. For this, we combined the latest data on epidemiol…
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Comparing the impact of three-dimensional digital visualization technology versus traditional microscopy on microsurgeons in microsurgery: a prospective self-controlled study.
[BACKGROUND] Emerging three-dimensional digital visualization technology (DVT) provides more advantages than traditional microscopy in microsurgery; however, its impact on microsurgeons' visual and nervous systems and delicate microsurgery …
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The natural course of idiopathic cervical dystonia.
Idiopathic cervical dystonia (ICD) is by far the largest subgroup of dystonia. Still, its natural course is largely unknown. We studied the natural course of 100 ICD patients from our botulinum toxin clinics (age at ICD onset 45.8 ± 13.5 ye…
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A roadmap for safety during facial filler injections: A fresh frozen cadaver study.
[BACKGROUND] Filler injections are commonly applied to reshape facial contouring. However, cadaveric injections of filler for facial contouring on the whole face, followed by anatomic analysis and measurement, have rarely been reported. Thi…
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Pivotal role of obliquus capitis inferior in torticaput revealed by single-photon emission computed tomography.
Torticaput is the most common primary form of cervical dystonia (CD). Obliquus capitis inferior (OCI) plays a major role in ipsilateral rotation of the head. The present study aimed to use single-photon emission computed tomography (SPECT/C…
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Safety and efficacy of botulinum toxin type A in preventing and treating scars in animal models: A systematic review and meta-analysis.
Previous studies have used botulinum toxin type A (BTXA) to improve postoperative and hypertrophic scars; however, there is lack of detailed verification on the safety and effectiveness of this approach. This study aimed to evaluate the the…
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Retroform Cervical Dystonia: Target Muscle Selection and Efficacy of Botulinum Toxin Injection.
[INTRODUCTION] Retroform cervical dystonia (RCD), which includes retrocaput and retrocollis, is a rare form of cervical dystonia. Few reports have been published on RCD. The present study aimed to characterize the target muscles involved in…
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Lantox-The Chinese Botulinum Toxin Drug-Complete English Bibliography and Comprehensive Formalised Literature Review.
In 1997, lanbotulinumtoxinA (LAN) was introduced in China. It is now available in Asia, Latin America and Eastern Europe under various brand names including Hengli, Lantox, Prosigne, Lanzox, Redux, Liftox, HBTX-A and CBTX-A. The literature …
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Efficacy of single-photon emission computed tomography aided botulinum toxin injection in cervical dystonia: A double-blind, randomized study.
[BACKGROUND] Although single-photon emission computed tomography (SPECT/CT) could help to predetermine dystonic muscles in patients with cervical dystonia (CD), its efficacy in aiding botulinum toxin injection is undetermined. This randomiz…
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Progressive disfiguring facial masses with pupillary axis obstruction from Morbihan syndrome: A case report.
[BACKGROUND] Morbihan syndrome is a rare illness, which presents with recurrent pitting edema on the upper two thirds of the face causing facial contour deformities, and Morbihan syndrome obstructing the pupillary axis with ptosis was seldo…
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Do complexing proteins provide mechanical protection for botulinum neurotoxins?
Botulinum toxin (BT) consists of botulinum neurotoxin and complexing proteins (CPs). CPs might provide mechanical protection for botulinum neurotoxin. As incobotulinumtoxinA (INCO, Xeomin®) does not contain CPs, we wanted to compare its mec…
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Comparing lanbotulinumtoxinA (Hengli) with onabotulinumtoxinA (Botox) and incobotulinumtoxinA (Xeomin) in the mouse hemidiaphragm assay.
LanbotulinumtoxinA (LAN) is manufactured and registered in China since 1994. Despite its widespread use in China and its increasing use in other Asian countries and in South America, it is not yet well known elsewhere. We wanted to compare …
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A Flexible Suspension Technique of Blepharoplasty: Clinical Application and Comparison with Traditional Technique.
[BACKGROUND] Double-eyelid blepharoplasty is one of the most popular aesthetic surgeries in China. But the traditional method produces a hidebound double eyelid due to its rigid suturing between the skin and the tarsus. The authors of this …
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Comparing incobotulinumtoxinA (Xeomin®) and onabotulinumtoxinA (Botox®): identical potency labelling in the hemidiaphragm assay.
Botulinum toxin (BT) is provided by several manufacturers producing a number of different drugs. Their potency is given in internationally standardised mouse units (MU). Clinical practise, however, reveals that the potency labelling of diff…
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Botulinum toxin therapy of hemifacial spasm: bilateral injections can reduce facial asymmetry.
Botulinum toxin (BT) is the treatment of choice for hemifacial spasm (HFS). When BT is injected into the affected side, patients may experience increased facial asymmetry. We wanted to evaluate in a prospective, randomised, placebo-controll…
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Antibody-induced failure of botulinum toxin therapy: re-start with low-antigenicity drugs offers a new treatment opportunity.
Botulinum toxin (BT) can stimulate formation of BT antibodies (BTAB) thus producing Antibody-Induced Therapy Failure (ABTF). BTAB titres may drop eventually. When BT therapy is then re-started with conventional BT drugs, BTAB titres re-incr…
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[Study on Rac1/MAPK/ERK pathway mediated mechanism and role in rats with ventilator induced lung injury].
[OBJECTIVE] To investigate the role of Ras-related C3 botulinum toxin substrate 1/mitogen-activated protein kinase/extracellular signal-regulated kinase (Rac1/MAPK/ERK) signal pathway in rats with ventilator induced lung injury (VILI) and i…
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Facial asymmetry in patients with hemifacial spasm before and after botulinum toxin A treatment.
Botulinum toxin A (BoNT-A) injection is one of the most widely used methods for hemifacial spasm (HFS) with high efficacy in controlling spasm. However, it is still unknown if esthetic symmetry could be desired as the spasm was controlled b…
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Polyclonal neural cell adhesion molecule antibody prolongs the effective duration time of botulinum toxin in decreasing muscle strength.
This study aimed to investigate if the effective duration time of botulinum toxin A (Btx-A) could be prolonged by polyclonal neural cell adhesion molecule antibody (P-NCAM-Ab). 175 male SD rats were randomly divided into three major groups:…
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Ultrasonic and viscoelastic properties of skin under transverse mechanical stress in vitro.
Ultrasound properties of rabbit and human skin tissues under transverse stress have been studied in vitro over the frequency range from 15 MHz to 40 MHz. B-scan images show significant increases in average dermal grey-scale levels for incre…