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Botulinum Toxin Type A for the Prevention of Migraines: An Umbrella Review of Systematic Reviews.

Toxins 2026 Vol.18(1)

Chamani G, Jasim H, Minston A, Dias MF, Poluha RL, Gonçalves DAG, Christidis M, Al-Moraissi EA, Christidis N, De la Torre Canales G, Ernberg M

PMC 전문 ↗ 원문 ↗ DOI ↗

관련 도메인

보툴리눔독소 주사 Botulinum Toxin Injection

Abstract

Botulinum toxin type A (BoNT-A) is an established preventive therapy for chronic migraines; however, uncertainty remains regarding its comparative efficacy and safety. Thus, we aimed to summarize current evidence from high-quality systematic reviews of the therapeutic effects of BoNT-A in migraine management. An umbrella review was conducted following PRISMA guidelines and registered in PROSPERO. High-quality systematic reviews with meta-analysis evaluating BoNT-A efficacy were identified through five databases up to August 2024. Primary outcomes included monthly headache frequency and severity. Methodological quality and risk of bias were assessed using the umbrella review checklist. Fourteen articles were included. Overall, quantitative evidence indicated favorable effects of BoNT-A compared with placebo for chronic migraines, across headache frequency, headache severity, and acute medication use, but less efficacy than topiramate and the CGRP monoclonal antibodies (CGRPmAbs) galcanezumab and fremanezumab. Though the adverse events were frequent, BoNT-A was generally well-tolerated. Comparative data suggested superior tolerability versus topiramate and a safety profile like CGRPmAbs. Although botulinum toxin type A is widely used as a preventive treatment for chronic migraines, the available evidence supports its efficacy at a moderate level. Further head-to-head and long-term analyses are needed to clarify its comparative role alongside newer biologic treatments.

추출된 의학 개체 (NER)

유형영어 표현한국어 / 풀이UMLS CUI출처등장
시술 botulinum toxin 보툴리눔독소 주사 dict 3
약물 topiramate C0076829
topiramate
 scispacy 1
약물 CGRP C0006669
Calcitonin Gene-Related Peptide
 scispacy 1
약물 galcanezumab C4694273
galcanezumab
 scispacy 1
약물 BoNT-A → Botulinum toxin type A scispacy 1
약물 fremanezumab scispacy 1
질환 Migraines C0149931
Migraine Disorders
 scispacy 1
질환 migraine C0149931
Migraine Disorders
 scispacy 1
질환 headache C0018681
Headache
 scispacy 1
기타 Botulinum Toxin Type A scispacy 1
기타 BoNT-A → Botulinum toxin type A scispacy 1
기타 CGRP scispacy 1

MeSH Terms

Migraine Disorders; Botulinum Toxins, Type A; Humans; Systematic Reviews as Topic

📑 인용 관계

이 논문이 참조한 문헌 46

외부 PMID 30건 (DB 미수집)

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필러 주입술 (21) 안검성형술 (14) 유방 (10) 안면거상술 (10) 지방흡입 (9) 코성형술 (8) 히알루론산 (7) 유방성형술 (6)

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