Hydroxychloroquine and lichen planopilaris: efficacy and introduction of Lichen Planopilaris Activity Index scoring system.
4/5 보강
TL;DR
Hydxychloroquine is effective in decreasing symptoms and signs in LPP and FFA as shown by significant reduction in the LPPAI in 69% and 83% of patients after 6 and 12 months of treatment, respectively.
PICO 자동 추출 (휴리스틱, conf 3/4)
유사 논문P · Population 대상 환자/모집단
환자: LPP, FFA, or both who were treated with hydroxychloroquine for up to 12 months from 2004 to 2007 at the University of California, San Francisco Hair Center
I · Intervention 중재 / 시술
hydroxychloroquine for up to 12 months from 2004 to 2007 at the University of California, San Francisco Hair Center
C · Comparison 대조 / 비교
추출되지 않음
O · Outcome 결과 / 결론
[LIMITATIONS] Retrospective analysis and uncontrolled study are limitations. [CONCLUSIONS] Hydroxychloroquine is effective in decreasing symptoms and signs in LPP and FFA as shown by significant reduction in the LPPAI in 69% and 83% of patients after 6 and 12 months of treatment, respectively.
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연도별 인용 (2012–2026) · 합계 202
OpenAlex 토픽 ·
Hair Growth and Disorders
Acne and Rosacea Treatments and Effects
Facial Rejuvenation and Surgery Techniques
Abstract 🌐 Abstract
[BACKGROUND] Lichen planopilaris (LPP) and its variant frontal fibrosing alopecia (FFA) are primary lymphocytic cicatricial alopecias for which there is no evidence-based therapy.
[OBJECTIVE] We assessed the efficacy of hydroxychloroquine in active LPP and FFA using the LPP Activity Index (LPPAI), a numeric score that allows quantification of the symptoms and signs of the condition for statistical comparison. In addition, we determined with the LPPAI if any improvement (reduction) in the numeric score pretreatment and posttreatment reached statistical significance.
[METHODS] This was a retrospective, single-center chart review of 40 adult patients with LPP, FFA, or both who were treated with hydroxychloroquine for up to 12 months from 2004 to 2007 at the University of California, San Francisco Hair Center. Symptoms, signs, activity, and spreading were scored at each visit in the standardized cicatricial alopecia flow chart. A numeric score was assigned to these markers of disease activity and a numeric score was calculated at each visit.
[RESULTS] There was significant reduction (P < .001) in the LPPAI at both 6 and 12 months. After 6 months, 69% had improved (reduced) symptoms and signs. At 12 months, 83% had improvement (reduction) in symptoms and signs.
[LIMITATIONS] Retrospective analysis and uncontrolled study are limitations.
[CONCLUSIONS] Hydroxychloroquine is effective in decreasing symptoms and signs in LPP and FFA as shown by significant reduction in the LPPAI in 69% and 83% of patients after 6 and 12 months of treatment, respectively.
[OBJECTIVE] We assessed the efficacy of hydroxychloroquine in active LPP and FFA using the LPP Activity Index (LPPAI), a numeric score that allows quantification of the symptoms and signs of the condition for statistical comparison. In addition, we determined with the LPPAI if any improvement (reduction) in the numeric score pretreatment and posttreatment reached statistical significance.
[METHODS] This was a retrospective, single-center chart review of 40 adult patients with LPP, FFA, or both who were treated with hydroxychloroquine for up to 12 months from 2004 to 2007 at the University of California, San Francisco Hair Center. Symptoms, signs, activity, and spreading were scored at each visit in the standardized cicatricial alopecia flow chart. A numeric score was assigned to these markers of disease activity and a numeric score was calculated at each visit.
[RESULTS] There was significant reduction (P < .001) in the LPPAI at both 6 and 12 months. After 6 months, 69% had improved (reduced) symptoms and signs. At 12 months, 83% had improvement (reduction) in symptoms and signs.
[LIMITATIONS] Retrospective analysis and uncontrolled study are limitations.
[CONCLUSIONS] Hydroxychloroquine is effective in decreasing symptoms and signs in LPP and FFA as shown by significant reduction in the LPPAI in 69% and 83% of patients after 6 and 12 months of treatment, respectively.
- p-value P < .001
Hydxychloroquine is effective in decreasing symptoms and signs in LPP and FFA as shown by significant reduction in the LPPAI in 69% and 83% of patients after 6 and 12 months of treatment, respectively
APA 7
Chiang, C., Sah, D., Cho, B. K., Ochoa, B. E., & Price, V. H. (2010). Hydroxychloroquine and lichen planopilaris: Efficacy and introduction of lichen planopilaris activity index scoring system.. Journal of the American Academy of Dermatology, 62(3), 387-92. https://doi.org/10.1016/j.jaad.2009.08.054
Vancouver
Chiang C, Sah D, Cho BK, Ochoa BE, Price VH. Hydroxychloroquine and lichen planopilaris: efficacy and introduction of Lichen Planopilaris Activity Index scoring system. Jour. Amer. Acad. Derm.. 2010;62(3):387-92. doi:10.1016/j.jaad.2009.08.054
AMA 11
Chiang C, Sah D, Cho BK, Ochoa BE, Price VH. Hydroxychloroquine and lichen planopilaris: efficacy and introduction of Lichen Planopilaris Activity Index scoring system. Jour. Amer. Acad. Derm.. 2010;62(3):387-92. doi:10.1016/j.jaad.2009.08.054
Chicago
Chiang, C., Sah, D., Cho, B. K., Ochoa, B. E., and Price, V. H.. 2010. "Hydroxychloroquine and lichen planopilaris: efficacy and introduction of Lichen Planopilaris Activity Index scoring system." Journal of the American Academy of Dermatology 62 (3): 387-92. https://doi.org/10.1016/j.jaad.2009.08.054
MLA 9
Chiang, C., et al. "Hydroxychloroquine and lichen planopilaris: efficacy and introduction of Lichen Planopilaris Activity Index scoring system." Journal of the American Academy of Dermatology, vol. 62, no. 3, 2010, pp. 387-92. doi:10.1016/j.jaad.2009.08.054.
PMID
20061052 ↗
🏷️ 키워드 / MeSH 📖 같은 키워드 OA만
인용 관계
그래프 OA 노드: 8/8 (100%)
· 참조 0편 · 후속 8편
이 논문을 인용한 후속 연구 20
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