Botulinum Toxin-A Dosing Trends for Adductor Spasmodic Dysphonia at a Single Institution Over 10 Years.
Abstract
[OBJECTIVES] This study aimed to identify the changes in dosing of botulinum toxin-A for adductor spasmodic dysphonia (ADSD) over a prolonged period.
[STUDY DESIGN] This is a retrospective chart review.
[METHODS] One hundred thirteen subjects treated for ADSD from 2003 to 2013 were identified from a clinical database. Subject age, gender, and total injection dose amount were all recorded for all subjects who had at least 10 injections.
[RESULTS] Fifty-four subjects met criteria for inclusion. There were no age or gender differences in the starting dose for subjects. Dosing decreased significantly compared with the second dose (5.05 ± 1.623 Units), by the sixth dose (4.26 ± 1.698 Units), and continued through the 10th dose (4.08 ± 2.019 Units) (P < 0.005 for all).
[CONCLUSIONS] Botulinum toxin-A dosing for ADSD decreases consistently over subsequent injections after the initial two dose titrations.
[STUDY DESIGN] This is a retrospective chart review.
[METHODS] One hundred thirteen subjects treated for ADSD from 2003 to 2013 were identified from a clinical database. Subject age, gender, and total injection dose amount were all recorded for all subjects who had at least 10 injections.
[RESULTS] Fifty-four subjects met criteria for inclusion. There were no age or gender differences in the starting dose for subjects. Dosing decreased significantly compared with the second dose (5.05 ± 1.623 Units), by the sixth dose (4.26 ± 1.698 Units), and continued through the 10th dose (4.08 ± 2.019 Units) (P < 0.005 for all).
[CONCLUSIONS] Botulinum toxin-A dosing for ADSD decreases consistently over subsequent injections after the initial two dose titrations.
추출된 의학 개체 (NER)
| 유형 | 영어 표현 | 한국어 / 풀이 | UMLS CUI | 출처 | 등장 |
|---|---|---|---|---|---|
| 시술 | botulinum toxin
|
보툴리눔독소 주사 | dict | 3 |
MeSH Terms
Acetylcholine Release Inhibitors; Botulinum Toxins, Type A; Dysphonia; Female; Georgia; Humans; Injections, Intramuscular; Laryngeal Muscles; Male; Middle Aged; Recovery of Function; Retrospective Studies; Stroboscopy; Time Factors; Treatment Outcome; Video Recording
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