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A randomized, active- and placebo-controlled study of the efficacy and safety of different doses of dutasteride versus placebo and finasteride in the treatment of male subjects with androgenetic alopecia.

🦱 탈모 🔵 RCT
무작위 임상시험 4/5 보강
Journal of the American Academy of Dermatology 📖 저널 OA 27.5% 2021: 51/103 OA 2022: 38/93 OA 2023: 34/109 OA 2024: 41/104 OA 2025: 38/165 OA 2026: 24/195 OA 2021~2026 2014 Vol.70(3) p. 489-498.e3 피인용 41회 cited 164 RCR 4.73 Hair Growth and Disorders
TL;DR Dutasteride increased hair growth and restoration in men with androgenetic alopecia and was relatively well tolerated.
Retraction 확인
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PubMed DOI OpenAlex Semantic 마지막 보강 2026-05-12
📑 코퍼스 인용 관계 · 인용됨 41
📑 인용한 논문 (6) ▾
연도별 인용 (2012–2026) · 합계 163
OpenAlex 토픽 · Hair Growth and Disorders Ovarian function and disorders Hormonal and reproductive studies

Gubelin Harcha W, Barboza Martínez J, Tsai TF, Katsuoka K, Kawashima M, Tsuboi R

PubMed ↗ DOI ↗ BibTeX ↓ RIS ↓

Abstract

[BACKGROUND] Dihydrotestosterone is the main androgen causative of androgenetic alopecia, a psychologically and physically harmful condition warranting medical treatment.

[OBJECTIVE] We sought to compare the efficacy and safety of dutasteride (type 1 and 2 5-alpha reductase inhibitor) with finasteride (type 2 5-alpha reductase inhibitor) and placebo in men with androgenetic alopecia.

[METHODS] Men aged 20 to 50 years with androgenetic alopecia were randomized to receive dutasteride (0.02, 0.1, or 0.5 mg/d), finasteride (1 mg/d), or placebo for 24 weeks. The primary end point was hair count (2.54-cm diameter) at week 24. Other assessments included hair count (1.13-cm diameter) and width, photographic assessments (investigators and panel), change in stage, and health outcomes.

[RESULTS] In total, 917 men were randomized. Hair count and width increased dose dependently with dutasteride. Dutasteride 0.5 mg significantly increased hair count and width in a 2.54-cm diameter and improved hair growth (frontal view; panel photographic assessment) at week 24 compared with finasteride (P = .003, P = .004, and P = .002, respectively) and placebo (all P < .001). The number and severity of adverse events were similar among treatment groups.

[LIMITATIONS] The study was limited to 24 weeks.

[CONCLUSIONS] Dutasteride increased hair growth and restoration in men with androgenetic alopecia and was relatively well tolerated.
🔬 핵심 임상 통계 (초록에서 자동 추출 — 원문 검증 권장)
  • p-value P = .003
  • p-value P = .004
📝 환자 설명용 한 줄

Dutasteride increased hair growth and restoration in men with androgenetic alopecia and was relatively well tolerated.

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↓ .bib ↓ .ris
APA 7 W, G. H., J, B. M., Tsai, T. F., Katsuoka, K., Kawashima, M., Tsuboi, R., Barnes, A., Ferron-Brady, G., & Chetty, D. (2014). A randomized, active- and placebo-controlled study of the efficacy and safety of different doses of dutasteride versus placebo and finasteride in the treatment of male subjects with androgenetic alopecia.. Journal of the American Academy of Dermatology, 70(3), 489-498.e3. https://doi.org/10.1016/j.jaad.2013.10.049
Vancouver W GH, J BM, Tsai TF, Katsuoka K, Kawashima M, Tsuboi R, et al. A randomized, active- and placebo-controlled study of the efficacy and safety of different doses of dutasteride versus placebo and finasteride in the treatment of male subjects with androgenetic alopecia. Jour. Amer. Acad. Derm.. 2014;70(3):489-498.e3. doi:10.1016/j.jaad.2013.10.049
AMA 11 W GH, J BM, Tsai TF, Katsuoka K, Kawashima M, Tsuboi R, et al. A randomized, active- and placebo-controlled study of the efficacy and safety of different doses of dutasteride versus placebo and finasteride in the treatment of male subjects with androgenetic alopecia. Jour. Amer. Acad. Derm.. 2014;70(3):489-498.e3. doi:10.1016/j.jaad.2013.10.049
Chicago W, G. H., J, B. M., Tsai, T. F., Katsuoka, K., Kawashima, M., Tsuboi, R., Barnes, A., Ferron-Brady, G., and Chetty, D.. 2014. "A randomized, active- and placebo-controlled study of the efficacy and safety of different doses of dutasteride versus placebo and finasteride in the treatment of male subjects with androgenetic alopecia." Journal of the American Academy of Dermatology 70 (3): 489-498.e3. https://doi.org/10.1016/j.jaad.2013.10.049
MLA 9 W, G. H., et al. "A randomized, active- and placebo-controlled study of the efficacy and safety of different doses of dutasteride versus placebo and finasteride in the treatment of male subjects with androgenetic alopecia." Journal of the American Academy of Dermatology, vol. 70, no. 3, 2014, pp. 489-498.e3. doi:10.1016/j.jaad.2013.10.049.
PMID 24411083 ↗
DOI 10.1016/j.jaad.2013.10.049

🏷️ 키워드 / MeSH 📖 같은 키워드 OA만

… 외 4개

인용 관계

그래프 OA 노드: 6/8 (75%) · 참조 0편 · 후속 6편

이 논문을 인용한 후속 연구 20

🏷️ 같은 키워드 · 무료전문 — 이 논문 MeSH/keyword 기반