The importance of dual 5alpha-reductase inhibition in the treatment of male pattern hair loss: results of a randomized placebo-controlled study of dutasteride versus finasteride.
🦱 탈모
🔵 RCT
무작위 임상시험
4/5 보강
TL;DR
Dutasteride increases scalp hair growth in men with MPHL and type 1 and type 2 5alpha-reductase may be important in the pathogenesis and treatment of MPHL.
📑 코퍼스 인용 관계
· 인용됨 54
📑 인용한 논문 (6) ▾
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연도별 인용 (2012–2026) · 합계 228
OpenAlex 토픽 ·
Hair Growth and Disorders
Dyeing and Modifying Textile Fibers
Cancer and Skin Lesions
Abstract 🌐 Abstract
[BACKGROUND] Male pattern hair loss (MPHL) is a potentially reversible condition in which dihydrotestosterone is an important etiologic factor.
[OBJECTIVE] Our aim was to evaluate the efficacy of the type 1 and 2 5alpha-reductase inhibitor dutasteride in men with MPHL.
[METHODS] Four hundred sixteen men, 21 to 45 years old, were randomized to receive dutasteride 0.05, 0.1, 0.5 or 2.5 mg, finasteride 5 mg, or placebo daily for 24 weeks.
[RESULTS] Dutasteride increased target area hair count versus placebo in a dose-dependent fashion and dutasteride 2.5 mg was superior to finasteride at 12 and 24 weeks. Expert panel photographic review and investigator assessment of hair growth confirmed these results. Scalp and serum dihydrotestosterone levels decreased, and testosterone levels increased, in a dose-dependent fashion with dutasteride.
[LIMITATIONS] The study was limited to 24 weeks.
[CONCLUSION] Dutasteride increases scalp hair growth in men with MPHL. Type 1 and type 2 5alpha-reductase may be important in the pathogenesis and treatment of MPHL.
[OBJECTIVE] Our aim was to evaluate the efficacy of the type 1 and 2 5alpha-reductase inhibitor dutasteride in men with MPHL.
[METHODS] Four hundred sixteen men, 21 to 45 years old, were randomized to receive dutasteride 0.05, 0.1, 0.5 or 2.5 mg, finasteride 5 mg, or placebo daily for 24 weeks.
[RESULTS] Dutasteride increased target area hair count versus placebo in a dose-dependent fashion and dutasteride 2.5 mg was superior to finasteride at 12 and 24 weeks. Expert panel photographic review and investigator assessment of hair growth confirmed these results. Scalp and serum dihydrotestosterone levels decreased, and testosterone levels increased, in a dose-dependent fashion with dutasteride.
[LIMITATIONS] The study was limited to 24 weeks.
[CONCLUSION] Dutasteride increases scalp hair growth in men with MPHL. Type 1 and type 2 5alpha-reductase may be important in the pathogenesis and treatment of MPHL.
Dutasteride increases scalp hair growth in men with MPHL and type 1 and type 2 5alpha-reductase may be important in the pathogenesis and treatment of MPHL.
APA 7
Olsen, E. A., Hordinsky, M., Whiting, D., Stough, D., Hobbs, S., Ellis, M. L., Wilson, T., & Rittmaster, R. S. (2006). The importance of dual 5alpha-reductase inhibition in the treatment of male pattern hair loss: Results of a randomized placebo-controlled study of dutasteride versus finasteride.. Journal of the American Academy of Dermatology, 55(6), 1014-23. https://doi.org/10.1016/j.jaad.2006.05.007
Vancouver
Olsen EA, Hordinsky M, Whiting D, Stough D, Hobbs S, Ellis ML, et al. The importance of dual 5alpha-reductase inhibition in the treatment of male pattern hair loss: results of a randomized placebo-controlled study of dutasteride versus finasteride. Jour. Amer. Acad. Derm.. 2006;55(6):1014-23. doi:10.1016/j.jaad.2006.05.007
AMA 11
Olsen EA, Hordinsky M, Whiting D, Stough D, Hobbs S, Ellis ML, et al. The importance of dual 5alpha-reductase inhibition in the treatment of male pattern hair loss: results of a randomized placebo-controlled study of dutasteride versus finasteride. Jour. Amer. Acad. Derm.. 2006;55(6):1014-23. doi:10.1016/j.jaad.2006.05.007
Chicago
Olsen, E. A., Hordinsky, M., Whiting, D., Stough, D., Hobbs, S., Ellis, M. L., Wilson, T., and Rittmaster, R. S.. 2006. "The importance of dual 5alpha-reductase inhibition in the treatment of male pattern hair loss: results of a randomized placebo-controlled study of dutasteride versus finasteride." Journal of the American Academy of Dermatology 55 (6): 1014-23. https://doi.org/10.1016/j.jaad.2006.05.007
MLA 9
Olsen, E. A., et al. "The importance of dual 5alpha-reductase inhibition in the treatment of male pattern hair loss: results of a randomized placebo-controlled study of dutasteride versus finasteride." Journal of the American Academy of Dermatology, vol. 55, no. 6, 2006, pp. 1014-23. doi:10.1016/j.jaad.2006.05.007.
PMID
17110217 ↗
🏷️ 키워드 / MeSH 📖 같은 키워드 OA만
인용 관계
그래프 OA 노드: 7/8 (88%)
· 참조 0편 · 후속 7편
이 논문을 인용한 후속 연구 20
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🏷️ 같은 키워드 · 무료전문 — 이 논문 MeSH/keyword 기반
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