Finasteride increases anagen hair in men with androgenetic alopecia.
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TL;DR
Evidence is provided that finasteride treatment results in favourable effects on hair quality that contribute to the visible improvements in hair growth observed in treated patients and provides direct evidence thatfinasteride 1 mg daily promotes the conversion of hairs into the anagen phase.
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연도별 인용 (2012–2026) · 합계 110
OpenAlex 토픽 ·
Hair Growth and Disorders
Facial Rejuvenation and Surgery Techniques
Salivary Gland Disorders and Functions
Abstract 🌐 Abstract
[BACKGROUND] The growth of scalp hair is a cyclical process of successive phases of growth (anagen) and rest (telogen). In previous clinical trials in men with androgenetic alopecia, treatment with finasteride increased scalp hair counts in a defined area (i.e. increased hair density).
[OBJECTIVES] The current study used a phototrichogram methodology to assess the effect of finasteride on the phases of the hair growth cycle.
[PATIENTS/METHODS] Two hundred and twelve men, age 18-40 years, with androgenetic alopecia were randomized to receive finasteride 1 mg daily or placebo for 48 weeks. At baseline and at 24 and 48 weeks, macrophotographs were taken to measure total and anagen hair count in a 1-cm(2) target area of the scalp.
[RESULTS] At baseline, mean total and anagen hair counts in the finasteride group were 200 and 124 hairs, respectively (% anagen = 62%) and the anagen to telogen ratio was 1.74 (geometric mean). In the placebo group, the respective values were 196 and 119 hairs (% anagen = 60%) and 1.57. At week 48, the finasteride group had a net improvement (mean +/- SE) compared with placebo in total and anagen hair counts of 17.3 +/- 2.5 hairs (8.3% +/- 1.4%) and 27.0 +/- 2.9 hairs (26% +/- 3.1%), respectively (P < 0.001). Furthermore, treatment with finasteride resulted in a net improvement in the anagen to telogen ratio of 47% (P < 0.001). In this study, treatment with finasteride 1 mg day(-1) for 48 weeks increased both total and anagen hair counts, and improved the anagen to telogen ratio.
[CONCLUSIONS] These data provide direct evidence that finasteride 1 mg daily promotes the conversion of hairs into the anagen phase. These data support that finasteride treatment results in favourable effects on hair quality that contribute to the visible improvements in hair growth observed in treated patients.
[OBJECTIVES] The current study used a phototrichogram methodology to assess the effect of finasteride on the phases of the hair growth cycle.
[PATIENTS/METHODS] Two hundred and twelve men, age 18-40 years, with androgenetic alopecia were randomized to receive finasteride 1 mg daily or placebo for 48 weeks. At baseline and at 24 and 48 weeks, macrophotographs were taken to measure total and anagen hair count in a 1-cm(2) target area of the scalp.
[RESULTS] At baseline, mean total and anagen hair counts in the finasteride group were 200 and 124 hairs, respectively (% anagen = 62%) and the anagen to telogen ratio was 1.74 (geometric mean). In the placebo group, the respective values were 196 and 119 hairs (% anagen = 60%) and 1.57. At week 48, the finasteride group had a net improvement (mean +/- SE) compared with placebo in total and anagen hair counts of 17.3 +/- 2.5 hairs (8.3% +/- 1.4%) and 27.0 +/- 2.9 hairs (26% +/- 3.1%), respectively (P < 0.001). Furthermore, treatment with finasteride resulted in a net improvement in the anagen to telogen ratio of 47% (P < 0.001). In this study, treatment with finasteride 1 mg day(-1) for 48 weeks increased both total and anagen hair counts, and improved the anagen to telogen ratio.
[CONCLUSIONS] These data provide direct evidence that finasteride 1 mg daily promotes the conversion of hairs into the anagen phase. These data support that finasteride treatment results in favourable effects on hair quality that contribute to the visible improvements in hair growth observed in treated patients.
- p-value P < 0.001
Evidence is provided that finasteride treatment results in favourable effects on hair quality that contribute to the visible improvements in hair growth observed in treated patients and provides direc
APA 7
D, V. N., Fuh, V., Sanchez-Pedreno, P., Lopez-Bran, E., Wolff, H., Whiting, D., Roberts, J., Kopera, D., Stene, J. J., Calvieri, S., Tosti, A., Prens, E., Guarrera, M., Kanojia, P., He, W., & Kaufman, K. D. (2000). Finasteride increases anagen hair in men with androgenetic alopecia.. The British journal of dermatology, 143(4), 804-10. https://doi.org/10.1046/j.1365-2133.2000.03780.x
Vancouver
D VN, Fuh V, Sanchez-Pedreno P, Lopez-Bran E, Wolff H, Whiting D, et al. Finasteride increases anagen hair in men with androgenetic alopecia. Brit. jour. derm.. 2000;143(4):804-10. doi:10.1046/j.1365-2133.2000.03780.x
AMA 11
D VN, Fuh V, Sanchez-Pedreno P, Lopez-Bran E, Wolff H, Whiting D, et al. Finasteride increases anagen hair in men with androgenetic alopecia. Brit. jour. derm.. 2000;143(4):804-10. doi:10.1046/j.1365-2133.2000.03780.x
Chicago
D, V. N., Fuh, V., Sanchez-Pedreno, P., Lopez-Bran, E., Wolff, H., Whiting, D., Roberts, J., Kopera, D., Stene, J. J., Calvieri, S., and .... 2000. "Finasteride increases anagen hair in men with androgenetic alopecia." The British journal of dermatology 143 (4): 804-10. https://doi.org/10.1046/j.1365-2133.2000.03780.x
MLA 9
D, V. N., et al. "Finasteride increases anagen hair in men with androgenetic alopecia." The British journal of dermatology, vol. 143, no. 4, 2000, pp. 804-10. doi:10.1046/j.1365-2133.2000.03780.x.
PMID
11069460 ↗
🏷️ 키워드 / MeSH 📖 같은 키워드 OA만
인용 관계
그래프 OA 노드: 8/8 (100%)
· 참조 0편 · 후속 8편
이 논문을 인용한 후속 연구 20
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