Comparison of spironolactone, flutamide, and finasteride efficacy in the treatment of hirsutism: a randomized, double blind, placebo-controlled trial.

Paolo Moghetti; Flavia Tosi; Antonella Tosti; Carlo Negri; Cosimo Misciali; Fabrizia Perrone; Marco Caputo; Michele Muggeo; Roberto Castello

doi:10.1210/jcem.85.1.6245

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Comparison of spironolactone, flutamide, and finasteride efficacy in the treatment of hirsutism: a randomized, double blind, placebo-controlled trial.

🟢 신뢰도 높음 · RCT (무작위 임상시험) 🧑 쉬운 모드

💡 한 문장 핵심

다모증 치료에서 spironolactone, flutamide, finasteride의 효능 비교: 무작위 이중맹검 위약대조 시험.

🦱 탈모 🔵 RCT

무작위 임상시험 4/5 보강

The Journal of clinical endocrinology and metabolism 📖 저널 OA 47.4% 2021~2026 2000 Vol.85(1) p. 89-94 피인용 9회 cited 255 OA RCR 4.32 Ovarian function and disorders

TL;DR After a 6-month course of therapy, the clinical efficacies of these drugs, at least at the doses used, are similar and are all effective in the treatment of hirsutism.

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📑 인용한 논문 (6) ▾

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Preparation and clinical evaluation of Finastride gel in the treatment of idiopathic Hirsu… Journal of drug assessment · 2015
Interventions for hirsutism (excluding laser and photoepilation therapy alone). The Cochrane database of systematic reviews · 2015
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연도별 인용 (2012–2025) · 합계 86

OpenAlex 토픽 · Ovarian function and disorders Hair Growth and Disorders Sexual function and dysfunction studies

Moghetti P, Tosi F, Tosti A, Negri C, Misciali C, Perrone F

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Abstract

To compare objectively the efficacies of spironolactone (100 mg/day), flutamide (250 mg/day), and finasteride (5 mg/day) in the treatment of hirsutism, 40 hirsute women were randomly assigned to double blind treatments with 1 of these 3 drugs or placebo for 6 months. Before and at the end of treatment, hirsutism was quantitatively measured in each subject by determination, by computer-assisted light microscopy, of the largest diameter of 5 hairs plucked from the linea alba. These measurements were averaged to produce a mean hair shaft diameter. For each subject, baseline and posttreatment assessments were carried out at the same time by an investigator blinded to both time and type of therapy. In addition, a semi-quantitative clinical evaluation was carried out by a modification of the Ferriman-Gallwey (F-G) scoring method, performed by a single investigator. At baseline the 4 groups of women had similar hair diameters and F-G scores. After 6 months of therapy all groups of subjects given active drugs showed reductions of their hair diameters, without statistically significant differences among groups (mean change +/- SEM, -11.7+/-5.6%, -18.0+/-6.1%, and -12.6+/-6.7%, respectively, in the spironolactone, flutamide, and finasteride groups). F-G scores were also significantly reduced in women receiving antiandrogen drugs, again without differences among groups (mean change, -41.0+/-5.5%, -38.9+/-7.2%, and -31.6+/-3.7%, respectively). No significant changes from baseline values were recorded by either hair diameter (-1.4+/-5.2%) or F-G score (+5.4+/-3.7%) assessment in the placebo group. In conclusion, spironolactone, flutamide, and finasteride are all effective in the treatment of hirsutism. After a 6-month course of therapy, the clinical efficacies of these drugs, at least at the doses used, are similar.

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After a 6-month course of therapy, the clinical efficacies of these drugs, at least at the doses used, are similar and are all effective in the treatment of hirsutism.

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APA 7 Moghetti, P., Tosi, F., Tosti, A., Negri, C., Misciali, C., Perrone, F., Caputo, M., Muggeo, M., & Castello, R. (2000). Comparison of spironolactone, flutamide, and finasteride efficacy in the treatment of hirsutism: A randomized, double blind, placebo-controlled trial.. The Journal of clinical endocrinology and metabolism, 85(1), 89-94. https://doi.org/10.1210/jcem.85.1.6245

Vancouver Moghetti P, Tosi F, Tosti A, Negri C, Misciali C, Perrone F, et al. Comparison of spironolactone, flutamide, and finasteride efficacy in the treatment of hirsutism: a randomized, double blind, placebo-controlled trial. Jour. clin. endo. meta.. 2000;85(1):89-94. doi:10.1210/jcem.85.1.6245

AMA 11 Moghetti P, Tosi F, Tosti A, Negri C, Misciali C, Perrone F, et al. Comparison of spironolactone, flutamide, and finasteride efficacy in the treatment of hirsutism: a randomized, double blind, placebo-controlled trial. Jour. clin. endo. meta.. 2000;85(1):89-94. doi:10.1210/jcem.85.1.6245

Chicago Moghetti, P., Tosi, F., Tosti, A., Negri, C., Misciali, C., Perrone, F., Caputo, M., Muggeo, M., and Castello, R.. 2000. "Comparison of spironolactone, flutamide, and finasteride efficacy in the treatment of hirsutism: a randomized, double blind, placebo-controlled trial." The Journal of clinical endocrinology and metabolism 85 (1): 89-94. https://doi.org/10.1210/jcem.85.1.6245

MLA 9 Moghetti, P., et al. "Comparison of spironolactone, flutamide, and finasteride efficacy in the treatment of hirsutism: a randomized, double blind, placebo-controlled trial." The Journal of clinical endocrinology and metabolism, vol. 85, no. 1, 2000, pp. 89-94. doi:10.1210/jcem.85.1.6245.

PMID 10634370 ↗

DOI 10.1210/jcem.85.1.6245

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그래프 OA 노드: 5/8 (63%) · 참조 0편 · 후속 5편

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