: An Enemy after Head and Neck Cancer Operations with Microvascular Free Flap Reconstruction?

Patients after head and neck cancer reconstructive surgical procedures are predisposed to have post-operative surgical site infections (SSI) develop. They are very often caused by multi-drug resistant strains, including as the most common one. The aim of the study was to determine important risk factors contributing to SSI of origin. The analysis included 134 head and neck cancer patients after salvage operations with microvascular free flap reconstruction. The was cultured in 27 of all 48 infected patients. The following risk factors were significantly associated with infection: re-hospitalization before reconstructive operation (p = 0.00011), massive blood loss (p = 0.00277), and need of revision surgical procedure (p = 0.00419). Of patients with infection, 48% were hospitalized in a general intensive care unit (ICU) after operation that, together with prolonged intubation, constituted a strong risk factor of that infection (p = 0.01077). Mean time of hospital stay was significantly longer in the group (58 days vs. 35 days; p = 0.02697). Our analysis identified a subset of head and neck cancer patients after salvage operation with microvascular free flap reconstruction who are at high risk of infection developing. Previously hospitalized patients with extensive blood loss and need of surgical revision necessitate increased monitoring for the development of this complication. Mechanical ventilation and hospital stay in an ICU should be shortened maximally or avoided in that challenging group of patients. Early recognition of patients at high risk remains a key point to prevent or limit the spread of infections.