CLWD: a Chinese histopathology dataset for lung adenocarcinoma subtype classification.

Effective diagnosis and treatment of lung adenocarcinoma depends on accurate typing, subtyping, and grading. Herein, we present the CLWD dataset, a valuable resource for the lung cancer pathology community, comprising 408 whole-slide images (WSIs) from 210 patients specifically curated for the study of lung adenocarcinoma subtypes. Scanned at 80 × magnification, it is one of the largest datasets in Asia, with a particular emphasis on Chinese patient demographics. Notably, the dataset includes comprehensive clinical information, such as age, sex, and diagnosis, providing a robust foundation for diverse research needs. Publicly accessible, it supports a range of applications, including machine learning model development and validation. An initial evaluation of lung adenocarcinoma subtype classification using a multi-instance learning framework demonstrated that this dataset can substantially advance global research and improve the accuracy of subtype diagnosis.